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Disertaciones |
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1
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KIMBERLY BRITO TECCHIO
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EVALUATION OF THE ANTITUMOR POTENTIAL AND CHARACTERIZATION OF MECHANISMS OF ACTION OF SYNTHETIC BETA-CARBOLINE ALKALOIDS IN HUMAN CELL LINEAGES
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Líder : FABIO VIEIRA DOS SANTOS
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MIEMBROS DE LA BANCA :
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FABIO VIEIRA DOS SANTOS
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GUSTAVO HENRIQUE RIBEIRO VIANA
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LUIZ FERNANDO DE CAMARGOS
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Data: 24-feb-2022
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Resumen Espectáculo
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Beta-carbolinic alkaloids are pharmacologically active compounds, widely distributed in the environment. According to the literature, they have already been shown to be effective in the treatment of several diseases, including cancer. Therefore, in the search for new antitumor agents, the present study aimed to evaluate the cytotoxicity of twelve different synthetic βcarbolinic alkaloids and, also, to evaluate the in vitro genotoxic and mutagenic potentials of two of the most promising of these alkaloids, called NQBio-006 and NQBio- 021, using the tumor cell lines TOV-21G (ovary) and MDA-MB-231 (breast). The two compounds were chosen after their cytotoxic potential screening using the MTT assay, since they displayed lower IC50 values and demonstrated promising selectivity index values in relation to the nontumor strain WI-26VA4, after 24-hour treatments. Genotoxic and Mutagenic potential were evaluated by performing the alkaline comet assay and the cytokinesis-block micronucleus assay, respectively, after 3-hour treatments, with and without metabolic activation. Cyclophosphamide and methyl methanesulfonate were used as positive control in the treatments with and without metabolic activation (S9 fraction), respectively. For the alkaloid NQBio-006, genotoxicity and mutagenicity tests were performed at concentrations of 0.6; 1.2; 1.9 and 2.5 in the TOV-21G line, while for the compound NQBio-021 concentrations of 0.4; 0.9; 1.7; 3.5; 5.2 and 6.9 were performed in the MDA-MB-231 strain. In addition, to verify selectivity, studies were conducted using WI-26VA4 at the same concentrations. The results showed that NQBio-006 did not induce primary DNA damage, with and without metabolic activation. However, the compound was shown to be mutagenic with and without S9 fraction, indicating that the compound acts by failure in chromosomal segregation. The compound NQBio-021 was genotoxic and mutagenic with and without S9, which indicates that this compound is capable of causing breaks in the DNA. However, none of them were genotoxic or mutagenic in WI-26VA4. In addition, to assess whether the compounds are good drug candidates, a prediction of in silico ADME (absorption, distribution, metabolism and excretion) parameters was performed. The results obtained showed that both alcaloids have antitumor potential, since they were cytotoxic and selective against the human tumor strains used and caused chromosomal changes that are related to the induction of cell death by apoptosis, according to the literature. However, additional studies must be carried out in vitro and in vivo to assess the efficacy and safety of these compounds in antitumor treatments
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2
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NATALIA DA CUNHA SEVERINO SAMPAIO
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INCIDENCE OF PULMONARY TUBERCULOSIS AND SOCIOECONOMIC CONDITIONS IN THE STATES OF THE SOUTHEAST REGION OF BRAZIL
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Líder : PAULO AUGUSTO MOREIRA CAMARGOS
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MIEMBROS DE LA BANCA :
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TAYNÃNA CÉSAR SIMÕES
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JOSÉ ROBERTO LAPA E SILVA
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ELIETE ALBANO DE AZEVEDO GUIMARAES
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PAULO AUGUSTO MOREIRA CAMARGOS
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RAFAEL GONCALVES TEIXEIRA NETO
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Data: 24-mar-2022
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Resumen Espectáculo
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Introduction: Despite the global reduction in infection and mortality rates, tuberculosis (TB) is still among the main public health problems with approximately ¼ of the world population infected by M. tuberculosis and one of the ten main causes of death by a single infectious agent. . In this scenario, despite efforts, goals to reduce morbidity and mortality from TB will not be achieved in Brazil. Given the importance of investigating the factors associated with the incidence of pulmonary TB, the hypothesis of this study concerns the limitation of social indicators, especially the Human Development Index (HDI) and Gini Index (GI), in predicting TB incidence rates. at the municipal aggregation level. Objective: to analyze the spatial correlation between the incidence of pulmonary TB, HDI, GA and other socioeconomic indicators in the southeastern region of Brazil. Methodology: This is a mixed analytical ecological study with time series and spatial aggregation in the municipalities (unit of analysis) of that region in the period 2010-2019 which, in turn, was subdivided into two others: 2010-2014 and 2015-2019, so that there was a comparison between consolidated from the first and the second period. Spatial smoothing methods were used for estimators of TB incidence, Global Moran Index and Univariate and Bivariate Local Spatial Association Indicator (LISA) and spatio-temporal analyzes with SatScan scan statistics for cluster detection and relative risk (RR) for occurrence of pulmonary TB. Spatial regression techniques were also used. Thematic maps were built for analysis of results. Results: With a significance level of 5% for the bivariate LISA, the Moran Index (I) showed a positive autocorrelation between TB incidence and HDI (I = 0.349), per capita income (I = 0.266), complete secondary education (I = 0.323) and intra-household agglomeration (I=0.093). There was a negative autocorrelation for GA (I = 0.144), infant mortality (I = 0.182), Theil-L index (I = 0.156) and the proportion of extremely poor (I = 0.125). In the space-time analysis, 16 probable clusters (p value < 0.05) were identified, mainly in the state of São Paulo. The most likely cluster (cluster nº 1) is located in the coastal region further south of Rio de Janeiro (RR = 2.37) in the period 2015 - 2019. The cluster with the highest relative risk (RR = 13.96) is located in the Midwest region of São Paulo from 2014 to 2018. In spatial regression, the GWR (geographically weighted regression) obtained significant results (p <0.05) for Theil index of work earnings, Gini index, intra-household agglomeration and Municipal HDI with the highest incidence of TB being associated with the worsening of social indicators in some regions. The spatial regression model (R²) explained between 46% and 77% of the variation in TB cases in some regions that were concentrated mainly in the north of Minas Gerais and the border with São Paulo (more to the southwest), state of Espírito Santo, most of the state of Rio de Janeiro and western region, São Paulo in the central region and border with Minas Gerais. Higher incidence of pulmonary TB was autocorrelated with better conditions of human development and income and weaker with intra-household crowding, lower inequality, lower infant mortality and proportion of the extremely poor. Conclusion: A spatial association was found between a higher incidence of pulmonary TB in regions with better human development indicators and greater social inequality, indicating a possible limitation of most of the analyzed indicators in predicting the occurrence of pulmonary TB in the municipalities of the Southeast region, with the exception of household crowding that was associated with a higher incidence of TB.
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3
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ROGÉRIO SANTOS FERREIRA
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FACTORS ASSOCIATED WITH GLYCEMIC CONTROL OF DIABETES MELLITUS TYPE 2 IN PATIENTS USING THE FHS IN A SMALL MUNICIPALITY SIZE IN THE INTERIOR OF MINAS GERAIS
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Líder : CLAUDIA DI LORENZO OLIVEIRA
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MIEMBROS DE LA BANCA :
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CLAUDIA DI LORENZO OLIVEIRA
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MARCIA CHRISTINA CAETANO ROMANO
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NAYARA RAGI BALDONI COUTO
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Data: 05-may-2022
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Resumen Espectáculo
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In the last decades, changes in the health/disease pattern have evidenced the rise of non-communicable chronic diseases. Type 2 diabetes mellitus (DM2) is an important public health problem and, due to its multifactorial etiology, requires a comprehensive and comprehensive approach to the patient. Due to its capacity for longitudinal care, primary health care plays an effective role in the prevention and treatment of this disease. This study aims to analyze factors associated with glycemic control in patients with DM2 treated in primary care in Carmo do Cajuru/MG. This is a population-based cross-sectional study using secondary data from medical records of primary health care patients. Sociodemographic, clinical and behavioral information were collected from patients with type 2 diabetes mellitus. From this information it was possible to draw a profile of the patients and relate it to glycemic control. A hierarchical cluster analysis was developed, using the Jaccard similarity method. Glycated hemoglobin was the variable used to classify the control or not of the disease and, in the absence of this data, we used fasting glucose. The results showed that most patients were female (59.67%), over 60 years old (65.45%) and overweight (70.92%). Few patients had a nutritional consultation (22.3%) or participated in health groups (19.92%). Only a minority had records of evaluations considered important by most current guides and guidelines: eye fundus (1.59%) and feet (2.39%) as well as referral to hyperdia strategies (10.36%). Almost half of the patients did not have adequate glycemic control. These results show us the need for a broader view of the patient with DM2 beyond the blood glucose tests.
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4
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WILLIAM NEVES OLIVEIRA
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PHARMACOTHERAPEUTIC FOLLOW-UP IN PATIENTS WITH TYPE 1 DIABETES MELLITUS NO SCOPE OF JUDICIALIZATION: A POSSIBILITY OF DIRECT COST OPTIMIZATION
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Líder : ANDRE DE OLIVEIRA BALDONI
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MIEMBROS DE LA BANCA :
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ADRIANA CRISTINA SOARES DE SOUZA
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ANDRE DE OLIVEIRA BALDONI
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LEONARDO RÉGIS LEIRA PEREIRA
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MARIANA LINHARES PEREIRA
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Data: 20-may-2022
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Resumen Espectáculo
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Background: The management of judicial demands for acquisition of medicines represents a challenge for the finances several Brazilian municipalities. The medications for the treatment of Diabetes mellitus (DM), especially insulin analogues, stand out as the items most demanded to the judicialization. However, access through for lawsuits doesn´t ensure the promotion of Rational use of medicines (RUM). This scenario, pharmacotherapeutic follow-up is a clinically effective strategy for patients with DM, but economic studies on this theme and population group are still incipient. Aim: To evaluate the direct medical costs one year after of pharmacotherapeutic follow-up service in type 1 diabetes mellitus (T1DM) patients receiving insulin analogues through to lawsuits on perspective of Brazilian Unified Health System (SUS). Methods: A quasi-experimental single-arm study with analysis of direct medical costs of T1DM patients using insulin analogues via judicialization. T1DM patients receiving insulin analogues by judicial decisions in a medium-sized municipality participated in the study. The pharmacotherapeutic follow-up was conducted according the Pharmacotherapy workup (PW) adapted method. Data were collected one year before the beginning of the intervention (baseline) and one year after its beginning (follow-up), using electronic medical records, hospital admission authorization, and data collected during the pharmacotherapeutic follow-up. Direct medical costs before and after pharmacotherapeutic follow-up were described, and the cost difference (followup - baseline) per patient was calculated. The time horizon set for the analysis was one year. Costs were adjusted to the year 2022, when earlier values were collected. Sensitivity analysis was performed to measure influence of the difference of each cost variable between pharmacotherapeutic follow-up and baseline on the total cost difference. Results: 28 patients completed all stages of the study. After pharmacotherapeutic follow-up, the total difference in direct medical costs was -R$19,274.16 and per patient was -R$688.36 (↓18.37%). Sensitivity analysis has shown 33.4% chance of the pharmacotherapeutic follow-up to reduce cost when compared to baseline. Conclusion: The findings suggest wich pharmacotherapeutic follow-up can reduce direct medical costs in SUS perspective of T1DM patients receiving medications through to lawsuits.
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5
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ESTER PONTES ALMEIDA
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PREVALENCE OF SARS-CoV-2 AND OCCUPATIONAL PROFILE INFECTION IN DELIVERIES DURING THE COVID-19 PANDEMIC IN MEDIUM-SIZED HUMANITY
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Líder : RAFAEL GONCALVES TEIXEIRA NETO
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MIEMBROS DE LA BANCA :
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RAFAEL GONCALVES TEIXEIRA NETO
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GUSTAVO MACHADO ROCHA
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MARCO AURÉLIO PEREIRA HORTA
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Data: 18-ago-2022
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Resumen Espectáculo
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Introduction: The new coronavirus (SARS-CoV-2), which causes the “Coronavirus Disease 2019” (COVID-19), was responsible for the emergence of a pandemic started in the first months of 2020. During social distancing, a group that drew attention was that of the delivery men, who during the pandemic expanded their activities. Its role in maintaining the economy was essential. Deprived of social guarantees related to the employment relationship, delivery men add the risks inherent to their mobility to the risks inherent to contamination by SARS-CoV-2. (AQUINO; PILATE; FELIX, 2020), making them possible vectors of the disease (ORTIZ-PRADO et al., 2021). Justification: The motivation of this dissertation was justified by the growing number of positive cases of COVID-19, the need to monitor the contamination rate among delivery man and investigate the association of factors that collaborated with the infection of delivery man by SARS-Cov-2. Objectives: To assess the prevalence of SARSCoV-2 infection in delivery man in a medium-sized city, at two different times of the pandemic, and to associate it with social and occupational risk factors that make the delivery man more susceptible to SARS-CoV- 2. Methodology: Clinical samples were collected in two stages to search for anti-SARS-CoV-2 antibodies and SARS-CoV-2 viral RNA in the same group of delivery man. Questionnaire about the social, occupational and preventive profile of COVID-19 was applied among the delivery man. The variables were measured using the Chi-Square and Mann-Whitney methods with a significance of 5%. Multiple logistic regression sought an association of measured factors with the positivity found. Results: There was an important increase in the total positivity of the second stage of collections (P=0.06), with a significant increase in the rapid test (p=0.03), when compared to the results of the first stage of collections. The amount of the positivity of the two stages resulted in a final prevalence of 15.4% (95% CI 0.0938-0.2322). Among the social characteristics, the level of education showed the greatest difference, although without significance (p=0.11) and a high number of delivery man had low education (36% had not completed high school). The delivery man knowledge about risk groups and symptoms was “High”, but regarding the forms of contagion during the work routine, it was only “Good”. Regarding preventive behavior, the group that said they “did not wash their hands” after going to the bathroom was significant (0.03). In the multiple logistic regression analysis, the variable “wash your hands after going to the bathroom” was the only variable that maintained a significant association with the outcome, so the chance of the delivery person being contaminated by SARS-CoV-2 was significantly higher among those who said not having the habit of “washing hands after going to the bathroom”. Conclusion: This work proved to be of high importance for the class of delivery men, as it went beyond the presentation of prevalence, involving socioeconomic, behavioral and working conditions characteristics, agreeing that there is a need for a labor legislation that benefits the entire class. We concluded that the prevalence among delivery men was high and that they were potentially exposed to the risk of contamination, contributing to the dissipation of SARS-CoV-2. Our findings are in agreement with other prevalences found in studies with delivery people (ORTIZ-PRADO et al., 2021) and in other studies that evaluated the prevalence of groups that worked in person during the pandemic.
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6
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Victor Antonio Ferreira Freire
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ASSESSMENT OF OXIDATIVE STRESS IN PREECLAMPSIA: SYSTEMATIC REVIEW AND META-ANALYSIS
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Líder : HERICA DE LIMA SANTOS
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MIEMBROS DE LA BANCA :
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CRYSTIAN BITENCOURT SOARES DE OLIVEIRA
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ESTELA MARIS ANDRADE FORELL BEVILACQUA
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HERICA DE LIMA SANTOS
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MELINA DE BARROS PINHEIRO INACIO
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Data: 26-ago-2022
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Resumen Espectáculo
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The preeclampsia is a hypertensive syndrome of pregnancy responsible by high rate of complications and morbimortality maternal and fetal. The understand about the role of inflammation, imbalance of anti-angiogenic factors and oxidative stress in the development of preeclampsia brought advance for the comprehension of its pathophysiology, but also showed different profiles between early and late PE. Therefore, this study search to review the oxidative stress profile in the PE subtypes and evaluate which markers are altered in blood and placental tissue. In September of 2021, a search was conducted in different databases such as MEDLINE, EMBASE, LILACS, and Web of Science without restriction of year and language of publication. The quality of the studies was evaluated by Newcastle-Ottawa scale and Joanna Briggs Institute for analytical Cross-Sectional Studies. From the 12,080 screened records, 62 were finally included in the systematic review. The markers of stress oxidative evaluated were those related to damage and antioxidant activity, such as malondialdehyde (MDA), lipid peroxides, hydrogen peroxide, oxide nitric (NO), advanced oxidation protein products, carbonylated protein, 8-hydroxy-2′-deoxyguanosine, total oxidant status, total antioxidant capacity (TAC), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione S-transferase and free glutathione. Meta-analysis revealed that the MDA levels in the blood and placenta were significantly increased in the combined PE, just as in mild and severe PE. Pregnant women with mild and severe PE were identified with low serum levels of NO. Markers related to TAC and enzymatic activity, including GPx, CAT, and SOD in mild PE, were significantly lower in the blood of pregnant women with PE. The results demonstrated that oxidative stress is related to the pathophysiology of PE, through increased lipid peroxidation, reduction of NO levels and the antioxidant capacity, like lower enzymatic activity of GPx, CAT, and SOD in PE. In addition, altered levels of MDA in placenta and blood show that placental changes have repercussions on the clinical syndrome.
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7
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Ludmila de Paula
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FREQUENCY OF ESKAPEE GROUP BACTERIA IN AN INTENSIVE CARE UNIT OF A REFERENCE HOSPITAL IN INFECTOLOGY IN MINAS GERAIS
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Líder : JAQUELINE MARIA SIQUEIRA FERREIRA
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MIEMBROS DE LA BANCA :
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JAQUELINE MARIA SIQUEIRA FERREIRA
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ROBERTA CARVALHO DE FIGUEIREDO
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MAGNA CRISTINA DE PAIVA
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ADRIANO GUIMARAES PARREIRA
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Data: 30-ago-2022
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Resumen Espectáculo
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Health Care-Related Infections (HAI) represent a public health problem, especially in relation to those caused by antimicrobial-resistant bacteria in intensive care units (ICU). HAIs are responsible for high rates of morbidity, longer hospital stay and mortality. The main bacteria causing HAI are Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aerugionosa, Enterobacter spp., and Escherichia coli belonging to the acronym ESKAPEE. In this context, the objective of this study was to estimate the prevalence of HAIs caused by bacteria of the ESKAPEE group in an adult ICU of a referral hospital in infectology in Minas Gerais. This is a cross-sectional study developed with 77 patients admitted to the ICU with a diagnosis of HAI caused by bacteria from the ESKAPEE group with microbiological evidence from January 1, 2017 to December 31, 2019. Data were collected from a search in the Hospital Management Integrated System (SIGH) and by active search in printed sheets in the Hospital Infection Control Service and in the Microbiology Laboratory. The comparison between groups (ESKAPEE and patients who had HAI) was made using the mean and standard deviation for the variable “age” and the difference in the mean between the groups was investigated using the Student's t test. Categorical variables were compared between groups using Pearson's chi-square test. The significance level adopted was 5%. A total of 1081 patients hospitalized during the study period were obtained. Of these, 112 patients had HAIs with microbiological evidence, and the overall prevalence of HAIs diagnosed by the SCIH was 10.36%. Of the total of 77 patients diagnosed with HAI by ESKAPEE, 50 (64.94%) were multidrug-resistant. No statistically significant associations were found between all variables analyzed. The mean age of patients who had HAI caused by bacteria from the ESKAPEE group was 47.97 years. All patients in the research used at least one invasive procedure, with the blood stream being the most affected site of infection in the ESKAPEE group. The microorganisms isolated from HAI caused by bacteria of the ESKAPEE group belong, for the most part, to the group of Gram-negative bacteria (87.60%). The most prevalent bacterial species of the ESKAPEE group were: Acinetobacter baumannii 26 (26.80%), then Klebsiella pneumoniae 23 (23.70%), Pseudomonas aeruginosa 23 (23.70%). The most prescribed classes of antimicrobials were glycopeptides followed by polymyxins. There vii was an expressive prevalence of HAI caused by Gram-negative bacteria and the most affected site was bloodstream infection. This result suggests a reassessment of the protocols and continuing education of health professionals.
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8
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ANA CAROLLINY FERNANDES FARIA
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EFFECT OF MATERNAL PINEALECTOMY ON OFFERS OF WISTAR RATS IN COMPARISON WITH THE OFFENS OF RATS TREATED WITH VPA: BIOCHEMICAL STUDY OF THE CEREBELLUM
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Líder : LEANDRO AUGUSTO DE OLIVEIRA BARBOSA
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MIEMBROS DE LA BANCA :
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ANA MARIA MARQUES ORELLANA
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LEANDRO AUGUSTO DE OLIVEIRA BARBOSA
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VANESSA FARIA CORTES
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Data: 30-ago-2022
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Resumen Espectáculo
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Autism (ASD) is a developmental disorder that causes changes even in early childhood in areas of communication, social interaction and learning, as well as in the ability to adapt. There are numerous genetic variations that can be considered as possible causes of ASD, but none of them are responsible for more than 1% of cases and many of these environmental factors are associated with melatonin (MEL) deficiency, a hormone synthesized by the pineal gland during the period dark at night. The chance of developing ASD is higher in newborns who have a late onset of breastfeeding or who are bottle-feeding, as there is an increased risk of having MEL deficiency and a greater likelihood of developing ASD. The activity of the Na,K-ATPase (NKA) it is involved in the maintenance of the Na+ and K+ gradient across the cell membrane, it is essential for the conduction of the nerve impulse and its malfunction may results in a reduction learning and memory capacity. Studies have already demonstrated a reduction in NKA levels; in the present study, it was evaluated through biochemical parameters, whether the absence of maternal MEL (pinealectomized rats) induces the development of TEA in pups and whether exogenous MEL replacement in pinealectomized rats is able to prevent or delay the appearance of TEA. Biochemical tests were performed on the cerebellum of offsprings Wistar rats after the 4th week of life. Previously, the rats were divided into 5 groups: (1) pinealectomized rats with melatonin supplementation (MEL group); (2) pinealectomized rats without melatonin supplementation (PTX group); (3) female rats who underwent pinealectomy surgical procedure without removing the pineal (SHAM group); (4) rats injected with sodium valproate on the 13th gestational day (VPA group) and (5) rats that did not undergo any procedures (CONTROL group). The activities of the enzymes Na,K-ATPase, Acetylcholinesterase, reduced Glutathione (GSH), Lipid peroxidation and H2O2 produced were analyzed, as well as the expression of the α1 isoform of Na,KATPase was also evaluated. Our results showed that there was an increase in total and α1 activities in the SHAM group compared to the CONTROL group and a significant reduction in α2/α3 activity in the MEL group compared to the PTX and SHAM group, however there were no significant differences in the expression of α1 isoform of NKA. All other analyzes showed no significant viii effect. Therefore, our results show that the SHAM group exerts peculiar effects on nociceptive responses in the brain and that melatonin has an action on the α2/α3 activity of NKA. The α3 subunit is mainly expressed in the pineal gland and α2 is also in large amounts in the brain, opening the possibility for further studies to be carried out to investigate this interaction and whether there is any change in the individual with ASD or neurodegenerative diseases
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9
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HYGOR KLEBER CABRAL SILVA
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ASSESSMENT OF USER SATISFACTION AND VALIDATION OF A SATISFACTION SCALE WITH TELEHEALTH SERVICE IN THE CARE OF COVID-19 CASES: SATIS-COVID
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Líder : CLAUDIA DI LORENZO OLIVEIRA
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MIEMBROS DE LA BANCA :
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ANDRESSA VINHA ZANUNCIO
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CLAUDIA DI LORENZO OLIVEIRA
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PEDRO HENRIQUE BATISTA DE FREITAS
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Data: 31-ago-2022
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Resumen Espectáculo
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The new coronavirus (COVID-19) pandemic has changed the social life in our planet, from January 2020 until now. It has changed ways of social and religious gathering, traveling and transports. All come and go system has been modified to prevent the virus (SARS-CoV-2) spread, the social isolation and people´s illness has brought panic, uprising and chaos in health care systems.
The exhaustion of hospital beds, disappearance of protective equipment and medical supplies from the commerce and shortage of human resources have brought the need for alternative and innovative forms of health care. Internationally, the primary care practice has had to change in response to the COVID-19 pandemic. Consequently, it has been seen an unprecedented increase in the telehealth tool use. It also emerges the need to provide quality, ethic, and satisfaction to the system users. The telemedicine is an important innovation, although little is known about patient satisfaction and how this alternative will modify the traditional clinical practice. This work is about the telehealth service evaluation with the proposal the users remotely access information and teleconsultations related to COVID-19, the service has been implemented in two municipalities in Minas Gerais (Divinópolis and Teófilo Otoni), because of the partnership between The Telehealth Network of Minas Gerais, Municipal Health Departments, and the Federal University of São João del-Rei. For data collection, the Satis-COVID scale has been applied through an interview with patients cared by the TeleCOVID system from 05/17/2020 to 02/28/2021, that has been adapted from a validated instrument, consisting of 10 items distributed in one dimension: “Diagnostic capacity and disease management”, “Satisfaction with access, with the assistance and the TeleCOVID System use”. The interview to evaluate the satisfaction with the received care has been performed by telephone contact. Initially, a descriptive analysis from the data obtained from eligible users that answered the scale had been performed and, subsequently, the correlation, construct, validity and internal consistency analysis of the global item and each dimension of the Satis-COVID scale were accomplished. In addition to presentation of the global and stratified satisfaction of users regarding the service received by TeleCOVID.
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10
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Dayanne Gabriela de Melo Marques
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SUMMARY AND QUALITY OF RECOMMENDATIONS FOR THE PRACTICE OF PHYSICAL ACTIVITY IN PREGNANT WOMEN WITH RISK FACTORS: A SYSTEMATIC REVIEW OF CLINICAL GUIDELINES.
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Líder : MELINA DE BARROS PINHEIRO INACIO
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MIEMBROS DE LA BANCA :
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MELINA DE BARROS PINHEIRO INACIO
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DIEGO GIULLIANO DESTRO CHRISTOFARO
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CRYSTIAN BITENCOURT SOARES DE OLIVEIRA
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Data: 07-dic-2022
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Resumen Espectáculo
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During the pregnancy process, the woman's body undergoes several physiological and anatomical changes, in all its systems, to provide better fetal development. The ability to adapt to the demands of pregnancy can suffer interference, especially when it comes to pregnant women considered at high risk. Physical activity (PA) is considered a protective factor against several pathologies and has many benefits. We know that the world's adult population does not practice enough PA, when evaluating the population of pregnant women, the prevalence is even lower. It is believed that the adherence to PA of pregnant women with risk factors is even lower than that of previously healthy pregnant women. Therefore, the objective of this Systematic Review was to summarize the recommendations reported in Clinical Guidelines (DCs) for the practice of PA in pregnant women with risk factors. A search was performed on MEDLINE (via Ovid), Web of Science, LILACS, EMBASE, PEDro, Google Scholar, and targeted websites. Initially, we estimated how often DCs provide PA recommendations for pregnant women with risk factors. Then, it was evaluated how high-risk pregnant women are described in DCs. Finally, we performed a synthesis and evaluation of the quality of DCs (by AGREE II), of the main recommendations regarding PA during pregnancy, in pregnant women considered at risk. There was variation between the recommendations for the prescription of frequency, duration, intensity and type of PA. However, aerobic activities, performed three times a week for at least 30 minutes, are the most recurrent recommendations. The quality of all DCs included in the study was considered high, with the lowest score in the domain of editorial independence (74.15%) and the highest, clarity of presentation (83.85%). However, further studies will be needed for greater consistency of recommendations.
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Tesis |
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1
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BRUNO DE SOUZA GONÇALVES
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EVALUATION OF THE NEUROPROTECTIVE EFFECT OF SEMISSYNTHETIC CARDIOTONIC STEROID BD-15 IN THE PREVENTION OF COGNITIVE DAMAGE AND NEUROTOXIC ACTIONS CAUSED DURING BRAIN ISCHEMIA
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Líder : LEANDRO AUGUSTO DE OLIVEIRA BARBOSA
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MIEMBROS DE LA BANCA :
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CRISTIANE QUEIXA TILELLI
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DUANE GISCHEWSKI PEREIRA
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JACQUELINE ALVES LEITE
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LEANDRO AUGUSTO DE OLIVEIRA BARBOSA
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VANESSA FARIA CORTES
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Data: 21-feb-2022
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Resumen Espectáculo
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A isquemia cerebral é uma das doenças com maior taxa de mortalidade atualmente. Entre as vítimas que não morrem, a maioria terá alguma incapacidade funcional como sequela. Portanto, quando se trata de isquemia, o problema não está relacionado apenas à mortalidade, mas também à incapacidade que acomete o indivíduo, como dificuldades de comunicação, alimentação e mobilidade, além de problemas de interação pessoal. Atualmente, o ativador do plasminogênio tecidual (rt-PA) é o único tratamento farmacológico para isquemia e não existem tratamentos com efeitos neuroprotetores para esta doença. Recentemente, os esteróides cardiotônicos (CTS) demonstraram promover neuroproteção contra a isquemia. No entanto, os CTS são drogas que possuem índice terapêutico estreito e sua utilização na clínica é restrita. O BD-15 é um novo derivado não tóxico da digoxina benzilidina que demonstrou aumentar diretamente a atividade da alfa3-Na,K-ATPase e prevenir a isquemia química em modelo de células N2a, mas nunca foi testado em um modelo de isquemia em animal. Relatamos aqui os resultados do uso de BD-15 contra danos cognitivos e ações neurotóxicas causadas durante a isquemia cerebral. Ratos Wistar foram divididos em 4 grupos (6 animais por grupo): Controle, Controle + BD 100 µg/kg tratamento, Isquemia e Isquemia + BD-15 100 µg/kg tratamento. A isquemia cerebral transitória foi induzida com oclusão bilateral de ambas as carótidas comuns artérias por 30 minutos, e após isso o animal foi acompanhado por três dias de reperfusão, com ou sem tratamento com BD-15 (uma dose por dia IP, 100 µg/kg) e o hipocampo foi coletado para realizar análises bioquímicas como: perfil lipídico e peroxidação e atividades enzimáticas de membrana (PMCA, SERCA e acetilcolinesterase); A análise histológica e os parâmetros comportamentais avaliados pelo teste de comportamento de campo aberto (os parâmetros avaliados foram o número de vezes que o animal mudou de quadrante, levantou o corpo e apresentou comportamento de autolimpeza e o número de visitas aos quadrantes centrais). Na análise histológica, a isquemia provocou um dano no tecido cerebral após 3 dias de reperfusão, e o tratamento com BD-15 foi capaz de diminuir esse dano. A isquemia provocou uma diminuição na atividade total da Na,K-ATPase e um aumento nos níveis de expressão da bomba e BD-15 impedem que as alterações causadas pela isquemia. O mesmo perfil foi encontrado para a atividade total de PMCA e os níveis de expressão de PMCA4. O BD-15 também foi capaz de prevenir a diminuição da atividade de SERCA, Mg-ATPase e acetilcolinesterase causada pela isquemia. A peroxidação lipídica da membrana (substância reativa ao ácido tiobarbitúrico), foi aumentada no grupo isquêmico, e novamente o BD-15 foi capaz de prevenir esse efeito. Em relação ao perfil lipídico, observamos aumento do conteúdo de fosfolipídios e colesterol no grupo isquêmico e diminuição nos grupos tratados com BD-15. Os parâmetros comportamentais demonstraram que o BD-15 previne o dano motor causado pela isquemia. Em conclusão, o BD-15 é um STC não tóxico que demonstra a prevenção de danos cerebrais provocados por isquemia, e parece promover neuroproteção em animais expostos à isquemia global.
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2
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MARIANA MARCOLINO COSTA
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EFFECT OF A PHYSICAL EXERCISE PROGRAM ON PLASMA CONCENTRATION OF ADIPONECTIN IN OVERWEIGHT AND OBESITY CHILDREN
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Líder : JOEL ALVES LAMOUNIER
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MIEMBROS DE LA BANCA :
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ALBA OTONI COLLARES
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FLÁVIO DINIZ CAPANEMA
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FRANCIANI RODRIGUES DA ROCHA
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JOEL ALVES LAMOUNIER
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WENDELL COSTA BILA
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Data: 25-mar-2022
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Resumen Espectáculo
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Introduction. Obesity is a state of chronic inflammation related to an increased risk for diseases, such as systemic arterial hypertension, atherosclerosis, dyslipidemias and diabetes mellitus type two; the control of obesity is a worldwide challenge. There is an inverse association between the level of physical activity, adiponectin plasma levels and the development of obesity, especially in children. Objective. To evaluate the impact of a physical activity intervention program on the adiponectin plasma concentration in overweight and obese schoolchildren. Method. This is a randomized, blinded, clinical intervention study with schoolchildren aged six to nine years, overweight and obese, from public schools in Ouro Preto, being a sample consisting of 79 children divided into a control and intervention group, submitted to a physical activity program for 10 months. Adiponectin levels, lipid profile, blood glucose, and body composition were evaluated. In the comparisons of means or medians between the groups, the Student T and Man Whitney U tests were used. In the comparison of variables in the same group, the Student T or Wilcoxon U tests were used. A comparação das variáveis no mesmo grupo foi feita pelos testes T de Student ou teste T de Wilcoxon. Results. In the intervention group, a reduction in the percentage of fat and triglycerides was observed, while in the control group there was a significant increase in BMI, total cholesterol and triglycerides and a reduction in blood glucose. No significant increase in adiponectin was observed. In the analysis of the difference between the control and intervention groups, weight, BMI, total cholesterol and triglycerides were statistically significant, which had greater reductions in the group submitted to physical activity. Conclusion. The effects of physical exercise over an extended period brought benefits to serum lipids, regardless of weight loss, but did not improve adiponectin levels, as without changes in body composition, exercise may have little or no effect on adiponectin.
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3
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JUSCELINO DE SOUZA BORGES NETO
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DEVELOPMENT OF MOTOR SKILLS FUNDAMENTALS IN SCHOOLS FROM 7 TO 10 YEARS: PERFORMANCE AND IMPACT OF SOCIAL ISOLATION ARISING FROM THE COVID-19 PANDEMIC
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Líder : JOEL ALVES LAMOUNIER
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MIEMBROS DE LA BANCA :
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ALISSON ARAUJO
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EDUARDO SERGIO DA SILVA
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JOEL ALVES LAMOUNIER
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JOSÉ VÍTOR VIEIRA SALGADO
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RODOLFO NOVELLINO BENDA
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WENDELL COSTA BILA
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Data: 19-abr-2022
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Resumen Espectáculo
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Motor development (DM) can be defined as the continuous changes in motor behavior throughout life, it is multicausal and inseparable from genetic and environmental factors. It can be divided into phases, among them, the fundamental movement phase in which the fundamental motor skills (HMFs) of stability, locomotion and manipulation are developed. The HMFs are the basis of the motor repertoire that leads in sequences to specialized movements and that, therefore, will be used to participate efficiently in organized and unorganized physical activities throughout life, and therefore, increases the chances of those who develop them. proficiently, to have a physically active lifestyle preventing the emergence of chronic non-communicable diseases. The objective of this research was to investigate the impact of the period of social isolation due to the Covid-19 pandemic on the development of HMFs of schoolchildren aged 7 to 10 years. This is a longitudinal study that observed the performance of students in HMFs. The study procedures were carried out in two stages, the first being before the beginning of social isolation due to the pandemic, in March 2020 (T1) and the second after the easing of social isolation and the return to face-toface classes in the educational system of Minas Gerais, in August 2021 (T2). The students were weighed and measured, the parents/guardians responded to an adapted anamnesis to identify the socioeconomic class of the family and inform the daily routine of the participants in T1 and T2, considering the social restrictions of isolation. To test the motor performance, the Test of Gross Motor Development – 3 (TGMD-3) was used. This test assesses 13 fundamental motor skills divided into the locomotion and ball skills subtests. The first study, which evaluated the DM and HMFs of schoolchildren in general and compared by sex, showed DM below what was expected for their age, especially in ball skills. Emphasis on the girls who were even worse than the boys, more specifically on the skills of bouncing and kicking the ball. It was concluded that the stimuli received by children throughout their lives, especially regarding manipulation skills, including in physical education classes, were not enough to develop the children's fundamental motor skills. Stratifying the participants, only those who were 10 years old were evaluated in terms of TGMD – 3 and routine in T1, as it is expected that at this age they would be proficient in DM as well as in HMFs. The results showed DM below the expected for the age. Most played at home (84.2%), had more than two hours a day to do whatever they wanted (73.7%) and did not participate in guided activity outside the context of physical education classes (68.4%) . They then showed better performance on the locomotion subtest (47.4% on average) than on the ball skills subtest (5.3% on average) (Chi-square X2 = 10.5; p = 0.04) . Therefore, it is possible to assume that the opportunities to perform tasks throughout life were more focused on the performance of locomotion activities than ball skills. However, due to low global motor performance, it is possible to infer that physical education classes alone are not enough for good performance in fundamental motor skills, both for boys and girls. The second study evaluated the impact of the period of social isolation on the development of schoolchildren's HMFs. According to the theory of human development, considering the maturational aspects, no type of worsening in performance from T1 to T2 was expected. And more than 60% of the students remained stable or got worse in the locomotion subtest, and 71.4 presented the same results in the ball skills subtest. Most participants increased the time spent with technological devices such as cell phones, computers and tablets, considered sedentary activities, also increased the time they slept and began to play more at home, which was statistically significant and has a negative association with the performance of children. fundamental motor skills. The proportion of participants who started to perform housework increased significantly, and this had a positive association with improved performance of locomotion skills. However, motor development is multicausal and inseparable from environmental factors, so an isolated fact does not explain the phenomenon as a whole. Therefore, it is concluded that the factors 10 associated with changes in the school's routine, together, influenced the development of HMFs, since this development is multicausal and is inextricably modified by genetic and environmental factors. And the findings reinforce this theory, that of dynamical systems.
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4
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VIRGÍNIA VITALINA DE ARAÚJO E FERNANDES LIMA PEREIRA
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CROSS-CULTURAL ADAPTATION OF INSTRUMENT FOR EVALUATION OF FUNCTIONALITY OF PATIENTS WITH HEAD AND NECK CANCER
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Líder : MICHELE CONCEICAO PEREIRA
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MIEMBROS DE LA BANCA :
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ALEXANDRE ERNESTO SILVA
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JOAO MARCOS ARANTES SOARES
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LUCIANA REGINA FERREIRA PEREIRA DA MATA
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MICHELE CONCEICAO PEREIRA
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VIVIANE GONTIJO AUGUSTO
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Data: 26-may-2022
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Resumen Espectáculo
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Head and neck cancer (HNC) and its therapeutic modalities have a strong impact on the functionality of patients, in addition to leading to stress, depression and difficulties in accepting body image. All these factors act in the patient's loss of self-esteem and social isolation, as well as restrictions in daily activities and worsening of quality of life. In this context, assessing body deficiencies, activity limitations and restrictions on participation, as recommended by the International Classification of Functioning, Disability and Health (ICF), becomes important. The aim of the present study was the cross-cultural adaptation, into Brazilian Portuguese, of a functional assessment instrument for patients with HNC (IAFCCP-br). This is a methodological study, developed in four stages: translation, synthesis, back-translation, review by an expert committee and pre-test. Two bilingual translators whose mother tongue was Portuguese translated the instrument into Portuguese and participated in the synthesis of the translation. Then, two translators whose mother tongue was English back-translated the Portuguese version into English. The content validation of the Portuguese version was carried out by a committee of ten professionals, who judged the semantic, idiomatic, cultural and conceptual equivalence of each item of the instrument. The pre-test of the adapted version was carried out at the Head and Neck Surgery Outpatient Clinic of the São João de Deus Health Complex with a nonrandom sample of 40 patients. In the translation, three discrepancies were identified between the translators, which were resolved in the translation synthesis phase. The two backtranslations confirmed that the Portuguese version accurately reflected the content of the original version. In content validation, the average agreement between evaluators was 95%. After the pre-test, adjustments were made, obtaining the Brazilian version of the IAFCCP-br. Cronbach's alpha for the questionnaire presented a value of 0,91. It is concluded that the IAFCCP-br was adapted to the Brazilian context, after cross-cultural adaptation.
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5
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PEDRO HENRIQUE BATISTA DE FREITAS
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ASSESSMENT OF THE QUALITY OF LIFE OF UNDERGRADUATE HEALTH STUDENTS IN FEDERAL HIGHER EDUCATION INSTITUTIONS: A MULTI-CENTRIC STUDY
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Líder : CLARECI DA SILVA CARDOSO
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MIEMBROS DE LA BANCA :
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CAMILA TEIXEIRA VAZ
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CLARECI DA SILVA CARDOSO
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DENISE ALVES GUIMARAES
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HELIAN NUNES DE OLIVEIRA
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NAYARA DORNELA QUINTINO
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Data: 09-jun-2022
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Resumen Espectáculo
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*
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6
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LUCIANA SOARES RODRIGUES
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DESCRIPTION OF BENZODIAZEPINENICS IN ELDERLY: FACILITATORS, DIFFICULTIES AND STRATEGY FOR IDENTIFICATION OF PATIENTS ELIGIBLE FOR THE PROCESS
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Líder : ANDRE DE OLIVEIRA BALDONI
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MIEMBROS DE LA BANCA :
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ANDRE DE OLIVEIRA BALDONI
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DANIEL NOGUEIRA CORTEZ
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JESSICA AZEVEDO DE AQUINO
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LILIANA BATISTA VIEIRA
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MARCIO GALVÃO GUIMARÃES DE OLIVEIRA
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MARIA AUXILIADORA PARREIRAS MARTINS
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Data: 10-jun-2022
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Resumen Espectáculo
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Introduction: Benzodiazepines (BZDs) are among the drugs with a high prevalence of consumption by the elderly population. They are indicated for shortterm therapeutic effects, and may cause undesirable effects, being a drug considered inappropriate for the geriatric population. Therefore, it is essential to plan strategies to rationalize the use of BZD among the elderly. Objectives: To develop tools that contributes to the process of deprescription of BZD in elderly users of the Unified Health System (SUS). Methods: This research was divided into two sub-studies. Substudy 1, corresponds to the elaboration and validation of an instrument on the facilitating and hindering aspects of the process of deprescription of BZD in the elderly, it is a study developed in three stages,namely: (1) methodological, represented by a review of literature, (2) semi-structured pilot interview with 25 elderly people undergoing clonazepam deprescription and (3) content validation using the Delphi technique. Asmeasures to evaluate the results obtained, the agreement of the evaluation wasanalyzed through the content validity coefficient (CVC). A value greater than or equal to 0.8 was considered as an acceptable level of agreement. Substudy 2 cross-sectional study that sought to analyze the possibility of identifying potential patients eligible for the deprescription of benzodiazepines through secondary data present in the medical records of the elderly. Data collection was carried out from July to November 2020. To identify potential patients who are candidates for deprescription, the following parameters were used: a) Insomnia record by itself or insomnia caused by comorbidity already undertreatment; b) Patients aged ≥ 60 years: using BZD regardless of duration. Results: In sub-study 1, validation was carried out by 50 specialists with training and/or experience in the area of Primary Health Care and/or Elderly Health, including doctors, pharmacists and nurses. The instrument was considered validated in the first evaluation round, in which all the items evaluated had a CVC greater than 0.8 in the experts’ assessment. However, they proposed suggestions for improvements that were incorporated into the final version of the questionnaire. In substudy 2, among the 332 medical records analyzed, 255 (76.8%) were female and 264 (79.5%) were aged between 65 and 70 years. Most patients performed prescription renewals 267 (80.4%) in an interval of xi zero to three months. A significant portion 202 (60.8%) did not contain information about the reason for prescribing BZDs and when considering the date of the first prescription, it was identified that most of the elderly 241 (72.6%) used it for a longer period of time. To six years. In the information obtained, only 17 (5.1%) presented eligibility criteria for deprescription. Conclusion: Substudy 1: The validated instrument presents itself as an important tool to be used by health professionals to optimize the BZD deprescription process, having an adequate clarity and validity index. Substudy 2: In view of the absence of data describe in the evolution of the patient treated at the Basic Health Units, in this study, it is possible to perceive the impossibility of using the medical records as a screening strategy for the identification of potential candidates for the deprescription of BZD.
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7
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GEISA CRISTINA DA SILVA ALVES
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Pharmacokinetic and pharmacodynamic (PK/PD) profile of piperacillin in critically ill patients from an Intensive Care Unit of a medium-sized hospital in the Midwest of Minas Gerais.
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Líder : ANDRE DE OLIVEIRA BALDONI
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MIEMBROS DE LA BANCA :
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KARIN JANNET VERA LOPEZ
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ADRIANA CRISTINA SOARES DE SOUZA
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ANDRE DE OLIVEIRA BALDONI
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CRISTINA SANCHES
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DANILO CESAR GALINDO BEDOR
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JAQUELINE MARIA SIQUEIRA FERREIRA
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Data: 06-jul-2022
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Resumen Espectáculo
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Introduction: Extended spectrum antimicrobial dosing strategies to reach the therapeutic target, especially for bacterial infections in critically ill patients, remains a challenge. Objective: To evaluate the pharmacokinetics (PK) and pharmacodynamics (PD) of piperacillin in critically ill patients in an Intensive Care Unit (ICU) in a medium-sized hospital in the Midwest of Minas Gerais. Method: This is a cross-sectional study, where the outcome of reaching the therapeutic target was evaluated in critically ill patients allocated in an ICU, using piperacillin. Individuals with indication of piperacillin use were recruited during a 12-month period. 03 blood samples were collected on the fifth day of treatment with piperacillin with two-hour intervals between each sample, and the antimicrobial in blood plasma was quantified by high performance liquid chromatography (HPLC). Reaching the therapeutic target was measured using the effectiveness parameter set at 50% and 100% of the time free concentrations were above the minimum inhibitory concentration (%fT>MIC) for a MIC of 8 mg/L. Clinical severity outcomes of patients included at 5, 7, 14, 28 and 30 days of ICU treatment with piperacillin were also evaluated. Data were expressed as medians, interquartile (IQ25%-75%), minimum and maximum values. Results: We included 30 patients, adults, aged 71 years (median: 61-78/IQ25%-75%), with a predominance of females 53% (n=16). Using 12g of piperacillin per day, infusion time of approximately 30 minutes, with intervals between doses of 8/8h, it was observed that 50% (n=15) of patients reached 50%fT>MIC, and 33% (n=15) =10) 100%fT>MIC. P.aeruginosa was the most prevalent bacterium, present in 20% (n=6) of the isolates from biological samples from the patients included. Conclusion: Reaching the therapeutic target in critically ill patients using empiric piperacillin is still quite controversial, and we believe that further studies are needed in this area.
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8
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ADRIANA BENATTI BILHEIRO
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Population characterization of triatomines in four environments in the Western Amazon: gallery forest, alluvial plain, campinarana and pasture.
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Líder : LUIS MARCELO ARANHA CAMARGO
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MIEMBROS DE LA BANCA :
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GENIMAR REBOUÇAS JULIÃO
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JADER DE OLIVEIRA
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JOAO ARISTEU DA ROSA
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LUIS MARCELO ARANHA CAMARGO
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SÉRGIO DE ALMEIDA BASANO
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Data: 05-ago-2022
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Resumen Espectáculo
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Triatomines are hematophagous insects, vectors of the protozoan Trypanosoma cruzi, ethiological agent of Chagas disease. The main transmission occurs in domestic and peridomestic cycles involving triatomine species and oral transmission. In recent years it has been observed outbreaks in the Amazon region mostly by the oral route. The aim of this study is the characterization of triatomine populations on four different environments on the Brazilian Amazon. The captures were conducted in four environments and Triatomine specimens were captured on Attalea speciosa palm trees. The specimens were identified by morphological and morphometric characters. Molecular analysis were conducted to identified blood meal sources and genotyping of T. cruzi in 6 DTUs. The identification of blood meal sources was conducted using a traditional PCR followed by Sanger sequencing of mtDNA cytb gene. Genotyping of T. cruzi in 6 DTUs was performed based on conventional multilocus PCR and the triatomines that were positive for T. cruzi and engorged with blood were also targeted for amplification of the cytB gene for identification of blood-meal sources. Sequencing was successful in 167 specimens and a total of 21 blood meal sources were identified: two reptilians, six birds, and 13 mammals. Of the 162 positive samples, the DTUs identified was TCI(87,65%) and TCIV(12,35%). It was observed that the 102 specimens were engorged with the most varied bloodmeals. Knowledge of the relationship between triatomines and possible reservoirs can help to elucidate the enzootic cycle of T. cruzi in the Amazon region and guide control strategies for Chagas disease transmission in that region.
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9
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ROMMEL LARCHER RACHID NOVAIS
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Assessment of body composition by imaging, anthropometry and bioimpedance methods in patients from the post COVID 19 rehabilitation service in Divinópolis-MG
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Líder : JOEL ALVES LAMOUNIER
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MIEMBROS DE LA BANCA :
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GUSTAVO MACHADO ROCHA
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JOEL ALVES LAMOUNIER
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JUSCELINO DE SOUZA BORGES NETO
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MARCIA CHRISTINA CAETANO ROMANO
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WENDELL COSTA BILA
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Data: 10-ago-2022
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Resumen Espectáculo
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Introduction: COVID-19 is a recent illness that has caused awareness in the scientific community due to its high transmissibility, the variety of the symptoms, and the unknown consequences in long term. Despite that, a worse prognosis between the illness and conditions related to body composition, such as obesity and sarcopenia, has been observed and, therefore, deserves attention, as well as the methods used to measure the body composition. Objectives: To study the quality of life, aspects of the disease, and the body composition of post-covid patients, comparing different methods such as anthropometry, bioimpedance (BIA), and ultrasound (US) with Dual-Energy X-Ray Absorptiometry (DEXA), evaluating The correlation and agreement of these methods. Methods: A observational study was developed, evaluating patients from the post-Covid outpatient in Divinópolis, Minas Gerais, with the collection of data relating to the quality of life, through the SF-36 questionnaire and the body composition, by BIA, anthropometry, ultrasound, And Dexa. Results: Concerning body composition, 44% of patients were classified as obese according to body fat mass index and 8% had an appendicular lean mass index compatible with low muscle mass measured by DEXA. 64% presented substantially increased abdominal circumference. About Covid-19, 47.6% needed hospitalization during the acute phase of the disease, 23.8% required mechanical ventilation, and 90% were already vaccinated. The quality-of-life data revealed that the worst-performance aspect was the limitation by emotional aspects (0.00) and the the physical limitation (25.00) and the best score was mental health (51.05). There was good reproducibility of the measurements of the adipose and muscular tissue by US with ICC greater than 0.90 in all anatomical regions. There was a moderate correlation between the DEXA A / G rate and the circumference of the waist and between the A / G rate with intra-abdominal fat measured by US (ICC = 0.567 and 0.563), respectively. As for lean mass, there was a positive moderate correlation between appendicular muscle mass measured by the US and the appendicular lean mass measured by DEXA, with a Spearman correlation of 0.620. About the percentage of body fat, only BIA presented an agreement with Dexa by the analysis of Bland Altman. Conclusion: Changes to the body composition were frequent, with the quality-of-life data revealing limitations of emotional and physical aspect in patients. Between body composition tests, BIA presented the best performance in the evaluation of adipose tissue compared to the gold standard. More widespread research is needed for the most in-depth knowledge of the characteristics of the postCovid symptomatic population and the validity of methods, such as US to evaluate body adipose tissue. Development and validation of specific equations for our population should be stimulated, positively influencing agreement with Dexa.
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10
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MICHAEL EDER DE OLIVEIRA
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EVALUATION OF ATORVASTATIN AND FLUCONAZOLE ASSOCIATED OR ASSOCIATED ACTION AGAINST AZOL-RESISTANT CANDIDA ALBIANS
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Líder : JAQUELINE MARIA SIQUEIRA FERREIRA
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MIEMBROS DE LA BANCA :
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JAQUELINE MARIA SIQUEIRA FERREIRA
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MAGNA CRISTINA DE PAIVA
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ADRIANA CRISTINA SOARES DE SOUZA
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FELIPE ROCHA DA SILVA SANTOS
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ADRIANO GUIMARAES PARREIRA
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Data: 23-ago-2022
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Resumen Espectáculo
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Among the pathogens caused by Candida albicans, intra-abdominal candidiasis (IAC) is the most severe manifestation of this pathogen. However, the therapeutic arsenal is limited, resistance is increasing, and there is low investment in research and development of drugs of this category. Given this scenario, the repositioning of drugs can be considered an important tool, as can already be observed for statins, which besides the known role in reducing cholesterol levels, have already demonstrated action against C. albicans. In this context, the aim of this study was to evaluate the action of atorvastatin alone or combined with fluconazole against fluconazole-resistant C. albicans ATCC10231 in in vitro and in vivo models. Previous results showed that atorvastatin has a minimal fungicidal concentration (MIC) of 128 µg/mL against C. albicans, but when combined with fluconazole, the MIC of atorvastatin was 0.25/0.01 µg/mL, while fluconazole (strain intrinsically resistant to this azol) was 0.01 µg/mL. In view of these values, the other assays of the work were developed. In the killing curve, the synergistic combination between atorvastatin and fluconazole showed action with 24 hours of treatment. In the prevention of biofilm formation, none of the two treatments were effective. In the pre-established biofilm, atorvastatin in the concentrations of 512 µg/mL and 256 µg/mL alone showed a reduction of biofilm of about 25% and 20%, respectively. In the synergic treatment, the concentrations (the first value referring to atorvastatin and the second to fluconazole) from 32/1,28 µg/mL to 8/0,32 µg/mL showed a reduction of around 50% in biofilm. In the in vivo model, using swiss mice aged 6 to 8 weeks, immunosuppressed with dexamethasone and infected with C. albicans ATCC10231 the treatment with atorvastatin alone showed a greater reduction of C. albicans in the liver, while the spleen showed a greater reduction of colonies with the synergistic treatment. The difference between the two organs may be related to the tropism of atorvastatin by the liver and its anti-inflammatory action by regulating TNF-α via NF-. Regarding the dosage of cytokines, the increase of IL-17 in the spleen treated alone with fluconazole is noteworthy. This is because IL-17 is produced in response to the presence of mannans (present in the wall of C. albicans). The survival curve showed that the animals treated synergistically ended the observational period in greater numbers with improvements in clinical signs. This demonstrates that drug repositioning has the potential to act as an important tool in the search for new antifungal protocols, mainly due to the low R&D investment in this area and emergence of new strains resistant to available treatments.
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11
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VIRGÍNIA PAULA FRADE
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PHARMACOKINETICS OF BENZNIDAZOL AND CORRELATION PK-PD
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Líder : CLAUDIA DI LORENZO OLIVEIRA
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MIEMBROS DE LA BANCA :
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CRISTINA SANCHES
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FARAH MARIA DRUMOND CHEQUER BALDONI
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FRANCISCO BERALDI DE MAGALHÃES
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GLAUCIA MARIA LOPES REIS
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JOSÉ EDUARDO GONÇALVES
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Data: 26-ago-2022
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Resumen Espectáculo
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Objective: The present study aimed to assess which is the best dose of benznidazole in the chronic phase of Chagas Disease, with better efficacy and less toxic effects, through a systematic review and a population pharmacokinetic model. Justification: Divergent results in research with the standard dose of 5mg / kg / day for 60 days in the chronic phase of the disease have been observed. Materials and Methods: The systematic review was conducted followed by meta-analysis and searches were performed in four databases, including studies published until May 2019. The descriptors used were: “Chagas disease”, “benznidazole”, “therapy medication ”,“ pharmacokinetics ”,“ dose-response relationship, medication ”and“ chronic disease ”. The meta-analysis compared studies using the standard dose of 5 mg / kg / day for 30 or 60 days. For the construction of the population kinetics model, a prospective cohort was carried out, in which patients with chronic Chagas' disease who are followed up at the Instituto de Infectologia Emílio Ribas were approached. Benznidazole was prescribed at a dose of 5mg / kg / day for 8/8 hours for 60 days. Two weeks after the start of treatment, blood samples were obtained to determine the concentration of the drug. Adverse events were assessed using a standardized questionnaire. Partial Results: In the systematic review, 23 articles were included and, of these, nine were selected for the meta-analysis. The selected studies were published between 1996 and 2018, with benznidazole dose regimens ranging from 2.5 mg / kg / day to 10mg / kg / day, lasting 30 to 80 days of treatment. Researches that used the standard dose for 30 days showed better results for the observed parameters (CRP, cardiac changes and negative serology) compared to those that used for 60 days. The prospective cohort included ten patients, with an average age of 50.3 years (SD = 5.62), the majority of whom were brown (90.0%) and female (60.0%). Adverse events have been reported after starting treatment, namely: diarrhea, pruritus, hypogeusia, liver dysfunction, oro-labial herpes, paresthesia, peripheral neuropathy, epigastric pain, dyspepsia / constipation and arthromyalgia. Conclusions: The results of the systematic review pointed to a great diversity of dosing schedules, indicating that there is still no consensus on the ideal dose schedule for benznidazole in the chronic phase of Chagas disease.
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12
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SIMONE DELGADO TOJAL
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TICKS AND INFECTION BY RICKETTSIA OF THE SMOKED FEVER GROUP IN TICKS IN EASTERN ACRE STATE, WESTERN BRAZILIAN AMAZON
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Líder : LUIS MARCELO ARANHA CAMARGO
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MIEMBROS DE LA BANCA :
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HERMES RIBEIRO LUZ
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JADER DE OLIVEIRA
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LUIS MARCELO ARANHA CAMARGO
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MATIAS PABLO JUAN SZABÓ
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SÉRGIO DE ALMEIDA BASANO
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Data: 30-ago-2022
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Resumen Espectáculo
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A variety of rickettsial agents, infecting different species of ticks, has been reported in Brazil. The Brazilian Amazon, despite its territorial extension and high diversity, presents timid records regarding the composition of the ixodofauna and its infection by rickettsial agents. The state of Acre, which is part of the Amazon region, has no recorded cases of Brazilian spotted fever, but there is a report of the agent Rickettsia parkeri strain Atlantic Forest as the only record of a pathogen infecting ticks in the Amazon. The aim of this study was to investigate Rickettsia infection of the spotted fever group in ticks in eastern Acre state, Brazil. From July 2019 to September 2021, Free-living ticks and parasitizing wild animals were collected in different locations in the state. Free-living ticks were sampled using visual inspection and trawling methods. As for ticks parasitizing wild animals, they were captured by traps (Pitfall, Tomahawk and mist nets) and by third-party host collection and occasional host collection methods. The ticks collected were identified by morphological analysis. Molecular analyzes were performed for 401 bp amplification of the citrate synthase gene (gltA), present in all Rickettsia spp. and subjected to a second test for amplifying a 532 bp fragment of the 190-kDa outer membrane protein (OmpA) gene, restricted to Rickettsia spp. of the spotted fever group. Ticks also submitted to protocols targeting a ≈460 bp fragment of the tick mitochondrial gene 16S rDNA. Ixodidae tick species are reported Amblyomma coelebs, Amblyomma latepunctatum, Amblyomma naponense, Amblyomma nodosum, Amblyomma oblongoguttatum, Amblyomma ovale, Amblyomma pacae, Amblyomma scalpturatum, Haemaphysalis juxtakochi, Rhipicephalus microplus and Amblyomma spp. larva, found free in the environment. Species A. coelebs, Amblyomma humerale, Amblyomma longirostre, A. naponense, A. nodosum, A. oblongoguttatum, A. ovale, A. pacae, Amblyomma rotundatum, A. scalpturatum, H. juxtakochi, Ixodes luciae and Amblyomma spp. and Ixodes sp. immature ticks, were found feeding naturally on Rhinella marina, Chelonoidis denticulatus, wild birds and mammals. In the study, the first record of the A. latepunctatum and H. juxtakochi species in the state of Acre was made. New associations between ixodids of the Amblyomma, Ixodes and Haemaphysalis genera, and of wild birds and mammals species have been described. Only one known vector for Rocky Mountain spotted fever, A. ovale species, was found free in the environment and parasitizing the lowland “caraxué-da-várzea” bird (Tamnophilus debilis), this being the first record of the parasite/host association between species. Amblyomma sp2 larva found in “mucura” (Didelphis marsupialis), parasitizing wild animals in the state of Acre. Rickettsia amblyommatis should be considered a potential human pathogen, since A. coelebs ticks often feed on humans in the Amazon. Future studies involving an investigation of rickettsial infection in the human population and wild and domestic reservoirs, as well as the investigation of other potentially pathogenic agents in the Amazon, are essential to implement epidemiological surveillance actions to prevent emerging diseases, transmitted by ticks of medical and veterinary interest. Research in search of description of new tick species and new reports of species, including soft ticks, are a priority in ixodofauna studies in the region of the state of Acre, especially in the border region with Peru.
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13
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DEBORAH FRANSCIELLE DA FONSECA
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EVALUATION OF SAFE CARE IN TELETHERAPY: CONSTRUCTION AND GRAPHIC PROTOCOL AND CHECKLIST VALIDATION
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Líder : JAQUELINE MARIA SIQUEIRA FERREIRA
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MIEMBROS DE LA BANCA :
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ANDREA BEZERRA RODRIGUES
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JAQUELINE MARIA SIQUEIRA FERREIRA
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JULIANO TEIXEIRA MORAES
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PATRICIA PERES DE OLIVEIRA
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THALYTA CRISTINA MANSANO SCHLOSSER
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VIVIANE EUZEBIA PEREIRA SANTOS
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Data: 12-dic-2022
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Resumen Espectáculo
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Identify and minimize risks, prevent incidents and improve SP, has been highlighted worldwide in high-risk clinical procedures, such as teletherapy, so the objective of this study was to build and validate a graphic protocol and checklist for the evaluation of safe patient care in oncological treatment by teletherapy. For this, a methodological study was made, with a mixed approach, subdivided into four stages: i) identification and synthesis of scientific evidence on patient safety in oncological treatment by teletherapy (scoping review), from the mnemonic combination: participants, Concept and context (PCC): P - oncological patient, C - patient safety and C - teletherapy treatment; ii) construction of a graphic protocol and checklist for the evaluation of safe patient care in oncological treatment by teletherapy, based on national and international guidelines and data scoping review (step 1), in addition to the components structure, process and result; iii) content and appearance validation of the graphic protocol and checklist, in two rounds by the Delphi technique; iv) application of a pilot study in a radiotherapy unit of Minas Gerais. The results were analyzed by descriptive statistics and the classification of care by applying the pilot study, from the score listed in the graphic protocol. In the scoping review, 67 studies were found that recommended the following measures to prevent and reduce the occurrence of incidents in teletherapy treatment: implementation of risk and process management programs; promotion of safe workflow; use of systems of voluntary notification of incidents and learning with them and promotion of SP culture. The graphic protocol and the checklist were built based on national and international guidelines and scientific evidence retrieved by the scoping review, being organized according to the Donabediana triad (structure, process and result). After the two rounds of Delphi, the graphic protocol and checklist were considered valid in content (CVC>90%) and appearance (CVC>90%). During the application of the pilot study, the graphic protocol and the checklist were suitable for use, that is, objective, easy to read and interpret, and no adjustments were necessary at the time of application. Thus, it was possible to construct and validate in content and appearance a graphic protocol and checklist for the evaluation of safe care to the patient in oncological treatment by teletherapy and aims to if this tool can contribute to improving management in teletherapy services and patient safety.
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14
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LETICIA GONCALVES RESENDE FERREIRA
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THROMBIN GENERATION AS A MARKER OF CARDIOVASCULAR EVENTS AND MORTALITY
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Líder : DANYELLE ROMANA ALVES RIOS
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MIEMBROS DE LA BANCA :
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CAMILA TEIXEIRA VAZ
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DANYELLE ROMANA ALVES RIOS
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GABRIELA MIANA DE MATTOS PAIXÃO
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LEILISMARA SOUSA NOGUEIRA
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RITA CAROLINA FIGUEIREDO DUARTE
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ROBERTA CARVALHO DE FIGUEIREDO
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Data: 16-dic-2022
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Resumen Espectáculo
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The thrombin generation assay (TGA) is a laboratory method that allows the global evaluation of hemostasis. The association between thrombin generation and cardiovascular events, especially acute myocardial infarction (AMI) and stroke, all-cause and cardiovascular mortality is still poorly investigated and the results are often inconsistent. Considering that cardiovascular diseases (CVDs) present in their pathophysiology a strong interaction between inflammation and hemostasis, thrombin, a key enzyme in the clotting process can be thought as a possible biomarker of cardiovascular risk. At the present work we review and summarize the results of the main studies that evaluated whether TGA parameters were associated with cardiovascular events, cardiovascular mortality and all-cause mortality and also evaluated whether TGA is associated with all-cause mortality in a prospective cohort of Brazilian adults.
Methods: The article search was performed between January and June 2022. The evaluation of association between TGA and all-cause mortality was performed with 2,588 participants at the baseline of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). TGA parameters lagtime, time-to-peak, peak, Endogenous Thrombin Potential (ETP) and normalized ETP (nETP) were evaluated according to the reference interval (RI). The association between TGA and all-cause mortality was estimated by Cox regression and adjusted for confounders.
Results: We included 13 studies in our review article. At second article, the mean follow-up time was 6.6± 2.7 years and 85 deaths occurred during the follow-up period. After adjustment, time-to-peak values above the RI at low and high tissue factor (TF) concentrations were associated with a higher risk of death [HR=2.45 (1.17-5.13) and HR=2.24 (1.02-4.93), respectively] and nETP and peak values below the RI at high TF concentration were associated with a higher risk of all-cause mortality [HR=3.85 (1.39-10.68) and HR=2.56 (1.17-5.61), respectively].
Conclusions: TGA can be a potentially interesting assay, also in subjects with CVDs, but its usefulness for clinical translation needs better understanding of the underlying determinants of thrombin generation.
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15
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HEULER SOUZA ANDRADE
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APPLICATION OF A HEALTH ECONOMIC MODEL TO ESTIMATE THE COST OF MAINTENANCE OF THE COLD CHAIN FOR THE CONSERVATION OF IMMUNOBIOLOGICALS IN BRAZIL
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Líder : ANDRE DE OLIVEIRA BALDONI
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MIEMBROS DE LA BANCA :
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ANDRE DE OLIVEIRA BALDONI
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ELIETE ALBANO DE AZEVEDO GUIMARAES
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TARCISIO LAERTE GONTIJO
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VALERIA CONCEICAO DE OLIVEIRA
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ALEXANDER ITRIA
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MAURILIO DE SOUZA CAZARIM
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Data: 19-dic-2022
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Resumen Espectáculo
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Immunobiologicals are thermolabile substances, which means that they need to be kept at an ideal temperature in order to preserve their characteristics and properties. In Brazil, the Ministry of Health, through the National Immunization Program, has a logistical structure that involves storage, conservation, manipulation, transport and distribution, to guarantee the conservation of these substances from the producing laboratory to the user, called Cold Chain . Like every service provided by any organization, maintaining the quality of the Cold Chain has a financial cost that needs to be measured and evaluated in order to achieve an efficient allocation of resources. This study aimed to analyze the costs of the Cold Chain for conservation of immunobiologicals at the municipal level. This is an economic evaluation research focused on cost analysis, carried out between the years 2020 and 2022. The study was divided into two stages: In the first stage, a checklist of activities was developed and validated using the Delphi technique. cost generators of the Cold Chain municipal instance, in order to have a more accurate description of the resources consumed in the process of conservation of immunobiologicals. After the validation process, the checklist consisted of 27 activities, 7 of them in the Transport and Receiving component, 18 in the Storage and Handling component and 2 in the Supervision and Permanent Education component. Considering all components, the checklist's total content validation index was 92.3%. Total internal consistency obtained a Cronbach's Alpha coefficient value of 0.9534. In the second stage, a study was carried out on the costing of the Cold Chain. The unit of analysis was the Municipal Instance. The perspective of the Unified Health System as a funder was considered, and the year 2021 as the time frame. A period of one year was considered as the time horizon of the analysis. Direct medical, non-medical, and indirect costs were included. ActivityBased Costing was used as a method to determine the cost and a sensitivity analysis was performed to identify the influence of the main categories on the final cost. In the period studied, the total cost of the Cold Chain was R$ 1,003,729.48, with non-medical direct costs being the most representative (61.24%). Human resources were the most influential items, both in direct medical and non-medical costs, representing 76.43% of the total cost. The study allowed the construction of a checklist of activities that generate reliable costs and valid content, becoming an important tool for assessing costs in the cold chain. It also allowed the determination of the total cost of the municipal Cold Chain as well as the main categories that influence this cost. Thus, the results are useful for planning the allocation of financial resources, as they provide valuable information for decision making, as well as for controlling variables that can influence final costs.
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16
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JULIANA MARA FLORES BICALHO
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EVALUATION OF THE IMPLEMENTATION OF THE PROGRAM TO PROMOTE PROPER AND HEALTHY FOOD IN PRIMARY HEALTH CARE IN MUNICIPALITIES OF MINAS GERAIS
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Líder : CLAUDIA DI LORENZO OLIVEIRA
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MIEMBROS DE LA BANCA :
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CLAUDIA DI LORENZO OLIVEIRA
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TARCISIO LAERTE GONTIJO
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DENISE ALVES GUIMARAES
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WANESSA DEBÔRTOLI DE MIRANDA
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RAQUEL DE DEUS MENDONÇA
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Data: 20-dic-2022
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Resumen Espectáculo
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Non-communicable chronic diseases constitute a health problem of great magnitude, one of its main determinants being inadequate nutrition. This scenario requires effective public policies that promote assistance, as well as the qualification of professionals for the development of health education actions, especially in Primary Health Care (PHC). The promotion of adequate and healthy eating (PAHE) must be composed of strategies that allow individuals and communities to carry out eating practices appropriate to their biological and sociocultural aspects, as well as the sustainable use of the environment. In this sense, the Program for the Promotion of Adequate and Healthy eating (PPAHE) was developed, in a practical and effective perspective, as a form of intervention to support the planning and development of collective actions of PAHE in PHC, with proposals for active methodologies and theoretical and practical support for the development of actions that can be carried out by all health professionals. However, having a Program is not enough, it is necessary to evaluate its implementation in order to subsidize the performance of the proposed intervention and the optimization of work processes in the planning and execution of educational actions and their results. In view of this, this research aims to evaluate the implementation of the PPAHE conducted by PHC professionals in the municipalities of Carmo do Cajuru and Nova Lima - MG. Before the evaluation itself, an Evaluability Study was carried out, considering document analyses, theoretical review, description of the intervention, elaboration of the Program's logical model, in addition to the identification and validation of the evaluative questions that resulted in the multidimensional measurement instrument to evaluate its implementation, identifying strengths and weaknesses. In the second moment, the evaluation of the implementation of the PPAHE was carried out through the research of mixed methods. The classification of the degree of implementation (DI) was calculated using the validated multidimensional measurement instrument (quantitative study), later there was the incorporation of qualitative data to explain the context of its implementation. In the quantitative approach, evaluative research was used from the perspective of implementation analysis. In the qualitative approach, an exploratorydescriptive study was carried out using content analysis. Qualitative and quantitative data were incorporated for analysis based on their imbrication. The DI of the program was 92.5% representing adequate implementation. In the imbrication of the data, the methodology of the actions proposed in the PPAHE and the carrying out of the Permanent Education activity emerged as converging strengths. Insufficient Human Resources for planning and executing the program, and the lack of a kitchen to carry out a cooking workshop were identified as challenges. It is concluded that the implementation of the program was adequate and could be extended to other Brazilian municipalities, in order to support professionals in structuring PAHE interventions in the PHC work routine. The PPAHE analyzed here intends to guide changes in practice with regard to the approach to health promotion by supporting PHC professionals to carry out practical and effective PAHE actions, in addition to being feasible in terms of time and available infrastructure. It is hoped that this research will contribute to the development and dissemination of more effective collective food and nutrition activities and to the qualification of professionals for this purpose. In addition to proposing indicators that contribute to better structuring the evaluation of actions, issues that are currently considered to be emerging.
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