Banca de DEFESA: ANNY TALITA MARIA DA SILVA

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : ANNY TALITA MARIA DA SILVA
DATE: 08/12/2022
TIME: 14:00
LOCAL: On line
TITLE:

Development of core-shell Molecularly Imprinted Polymers for the determination of antihypertensive drugs in biological fluids

KEY WORDS:

Molecularly imprinted polymersPolímeros, antihypertensive, sample preparation, capillary electrophoresis, high performance liquid chrimatography

PAGES: 138
BIG AREA: Ciências Exatas e da Terra
AREA: Química
SUMMARY:

The search for new adsorbent materials, which have greater chemical, physical and thermal stability, in addition to greater adsorption capacity, has been growing in the scientific research. The synthesis of core-shell materials has been widely explored and has shown to be advantageous in several areas, including applications as adsorbent material. In this work core shell materials were developed employing different colors (iron oxide, silica and metal-organic structure) and using molecularly imprinted polymers – MIPs – as a coating. The synthesized MIPs have the same reagents: terephthalic acids as a functional monomer, ethylene glycol dimethacrylate as a cross-linking agent, benzalkonium chloride as a surfactant, 4,4'-azo-bis-(4-cyano pentaenoic) as a radical initiator, and, finally, acetonitrile and dimethyl sulfoxide as solvents. However, the template molecule was varied, always using antihypertensive drugs (atenolol, carvedilol and amlodipine), which are widely used in society. Through the characterizations, it was possible to observe that the synthesized materials (MMIP, core@mMIP and MOF@mMIP) reached the objective of having a core-shell structure, in addition to demonstrating thermal stability and a surface with heterogeneous particles conducive to adsorption processes. All materials were used as adsorbents in sample preparation techniques, and these techniques (magnetic solid phase extraction, microextraction by packed sorbent and dispersive solid phase extraction) have the advantages of employing less sample and solvent volume and less mass. of adsorbent, so they produce little waste. The materials proved to be
good adsorbents, with recovery values when used in sample preparation greater than 70%. The methods developed with these materials and the sample preparation techniques followed by the analyzes in the analytical equipment are shown to be effective for the extraction of antihypertensive drugs from biological fluids.

BANKING MEMBERS:
Presidente - 1872495 - KEYLLER BASTOS BORGES
Interna - 2254152 - MAIRA NICOLAU DE ALMEIDA
Externo à Instituição - LEANDRO AUGUSTO CALIXTO - UNIFESP
Externo à Instituição - EDUARDO COSTA DE FIGUEIREDO - UNIFAL-MG
Externo à Instituição - JOSÉ LUIZ DA COSTA - UNICAMP