Banca de QUALIFICAÇÃO: IARA AMORIM CARVALHO

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : IARA AMORIM CARVALHO
DATE: 21/06/2023
TIME: 13:15
LOCAL: On line
TITLE:

Synthesis and characterization of polypyrrole-based adsorbent materials used in miniaturized sample preparation techniques for the determination of drugs in biological samples

KEY WORDS:

Polypyrrole; adsorbent; miniaturized techniques; drugs; biological fluids.

PAGES: 49
BIG AREA: Ciências Exatas e da Terra
AREA: Química
SUMMARY:

Two adsorbent materials called PPy-HM-BSA and MMPPy were synthesized and used together with new simple and fast analytical methods for the determination of enalapril and progesterone in biological samples. These adsorbent materials were characterized using DXR to determine their crystalline structure, FTIR to determine the functional groups present in their chemical composition, SEM to observe the morphological structure of the surface of the material, EDS to make a semiquantitative analysis of the elements present in the chemical composition, TGA to determine the temperature at which these materials can be used without compromising their properties, also seeking information on the synthesis and wettability steps to analyze the hydrophilicity or hydrophobicity of the materials. The determination of enalapril by EC proved to be efficient and reproducible. The coated PPy-HM-BSA excluded more proteins than the uncoated material by the protein exclusion test. PT-SPE proved to be a simple, fast-handling and versatile technique, which uses small amounts of solvent and also material and good extraction efficiency (74%). The determination of progesterone by HPLC proved to be efficient and reproducible. MSPE proved to be a simple, fast-handling and versatile technique, which uses small amounts of solvent and also material, achieving excellent extraction efficiency (~100%).

BANKING MEMBERS:
Interno - 1942302 - VICTOR AUGUSTO ARAUJO DE FREITAS
Interno - 1727278 - LUIZ GUSTAVO DE LIMA GUIMARAES
Externa ao Programa - 1348442 - PATRICIA BENEDINI MARTELLI