Banca de DEFESA: RAIRA DA CUNHA

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : RAIRA DA CUNHA
DATE: 13/03/2024
TIME: 13:30
LOCAL: On line
TITLE:

Synthesis and characterization of magnetic nanoparticles coated with polyaniline aiming for application in adsorption studies and sample preparation for diclofenac

KEY WORDS:

HPLC-UV, adsorption studies, sample preparation, polyaniline, MIP, diclofenac, human urine.

PAGES: 87
BIG AREA: Ciências Exatas e da Terra
AREA: Química
SUBÁREA: Química Analítica
SPECIALTY: Separação
SUMMARY:

The purpose of this study was to synthesize different materials based on polyaniline (PAni) with magnetic properties, with one of the materials being a molecularly imprinted polymer (MIP), to use them as adsorbent materials in adsorption studies in aqueous media and sample preparation in urine, and finally, to selectively determine diclofenac (DCF) in aqueous solution and human urine by high-performance liquid chromatography coupled with ultraviolet-visible detection. The potential of applying PAni as an adsorbent material was evaluated in adsorption studies in aqueous solution, assessing the following parameters: pH, kinetics, concentration, and temperature. The potential application of MIP was employed in magnetic solid phase extraction for the determination of DCF in urine. The optimization of the technique was performed aiming for the highest DCF recovery, as well as the elimination of interferents present in matrix. Thus, some parameters were optimized, such as sample pH, type and volume of eluent, amount of adsorbent material, sample volume, and agitation time. The performance criteria of the analytical method, including selectivity, linearity, precision, accuracy, limits of detection, and quantification were evaluated and showed results according to recommended criteria. The developed methods were successfully applied to human urine samples. 

BANKING MEMBERS:
Presidente - 1872495 - KEYLLER BASTOS BORGES
Interno - 1443844 - MARCO ANTONIO SCHIAVON
Externa ao Programa - 1954071 - MARIA CRISTINA SILVA
Externa à Instituição - MARIANE GONÇALVES SANTOS - UNIFAL-MG
Externo à Instituição - LEANDRO AUGUSTO CALIXTO - UNIFESP