Banca de DEFESA: MAYRA ASEVEDO CAMPOS DE RESENDE

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : MAYRA ASEVEDO CAMPOS DE RESENDE
DATE: 24/03/2022
TIME: 09:00
LOCAL: São João del Rei
TITLE:

Development of a Disposable Electrochemical Immunosensor based on Graphite Ink and Gold Nanoparticles for the Determination of the Cardiac Biomarker Troponin I

KEY WORDS:

Conductive Ink. Disposable Immunosensor. Electroanalytical. Heart. Troponin I

PAGES: 182
BIG AREA: Ciências Exatas e da Terra
AREA: Química
SUBÁREA: Química Analítica
SPECIALTY: Eletroanalítica
SUMMARY:

Heart disease and world organizations, in an overview of the escalation of the world's leading causes of death. These diseases cover any dysfunctions in the circulatory system and also in the heart muscle, some of them being cardiomyopathy, cardiac function, hypertension, stroke, among others. Mainly due to difficulties in diagnosis and provision in providing early care, Acute Myocardial Infarction is one of the most worrying diseases that affect the beginning of the heart. Basically, the diagnosis of infarction is given at the beginning, the electrogram exams and by means of serological tests that are similar to those of specific biomarkers of any organism. The latter need to be fast, effective and with easier needs to meet clinics. Not only cardiovascular diseases, but also several other diseases require tests to identify biomarkers, which facilitate the diagnosis and control of the disease. It is in view of this need for serological tests that there is a development of fast, low-cost and high-efficiency technologies. In this sense, as electroanalytical methodologies are highlighted in the production of biosensors. It presents itself with these uses of cheap materials, systems with few, reduced of reagents and equipment, attending to different methodologies. In addition, chemical materials can be constructed as different materials, including different materials for their capacity, such as materials, allowing for multiple sensors. When in the implicit and/or disposable modality, these sensors still have low cost, ease of large-scale production and this greatly facilitates their application. Given the above, the objective of this work is the development of a disposable electrochemical immunosensor capable of identifying and quantifying the cardiac biomarker Troponin I in blood and human saliva samples. The development of the sensor outlines all the development steps from the printed electrode to the immunosensor itself. This will work like ink manufacturing tools, as well as developing some manufacturing devices, as well as developing some manufacturing devices, such as developing some manufacturing devices, such as developing all sensor features. the antibody and antigen incubation time. In addition, this sensor was applied to a real identification sample of Troponin I blood and saliva, being made of interferents, sensitivity and certain limits of quantification and detection of the sensor.

BANKING MEMBERS:
Presidente - 1677150 - ARNALDO CESAR PEREIRA
Interno - 1727278 - LUIZ GUSTAVO DE LIMA GUIMARAES
Externo à Instituição - LUCAS FRANCO FERREIRA - UFVJM