Banca de DEFESA: LUCAS SANTOS AZEVEDO

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : LUCAS SANTOS AZEVEDO
DATE: 27/10/2020
TIME: 13:30
LOCAL: Campus Centro Oeste Dona Lindu
TITLE:

Evaluation of antioxidant and larvicidal activities of ethereal extract, fatty acids and methyl esters obtained from  Tecoma stans seeds (L.) Juss. Ex Kunth (Bignoniaceae)

KEY WORDS:

Secondary metabolites, Culex quinquefasciatus, Plantae extract and fractions.

PAGES: 64
BIG AREA: Outra
AREA: Multidisciplinar
SUMMARY:

Search for substances of natural sources which can be used as captors of free radicals and/or larvicide is a scientifically stimulating and intellectual subject because it has therapeutic potential for preventing degenerative diseases, such as Parkinson's and Alzheimer's, cardiovascular diseases, neoplasms, even in combating the proliferation of culicids, responsible for the spread dengue, Zika virus and filariasis. The products most used against mosquitoes contain artificial, non-biodegradable, and bioaccumulative substances. Many species in the Plantae kingdom have developed defense mechanisms for their survival that can be used with other perspectives, such as the synthesis of secondary metabolites. It is well described in the literature that vegetable oils have antioxidant and larvicidal activities. There are studies of Tecoma stans leaf and flower biological activities, but studies with their seeds are scarce. The work objective was to obtain and evaluate the antioxidant and larvicidal activities of the ethereal extract (EE), fatty acids (AG) and fatty acid methyl esters (FAME) obtained from T. stans seeds. EE showed presence of steroids, terpenes and alkaloids, also showed antioxidant potential (EC₅₀ = 0.92 µg/mL), was non-toxic to Artemia salina (DL₅₀ > 1000 µg/mL) and had moderate toxicity to Culex quinquefasciatus (DL₅₀ = 188.27 µg/mL). FAME showed antioxidant activity (EC₅₀ = 1.03 µg/mL), was toxic to A. salina (DL₅₀ = 7.52 µg/mL) and little toxic to C. quinquefasciatus (DL₅₀ = 449.03 µg/mL). AG showed antioxidant activity (EC₅₀ = 0.91 µg/mL), was little toxic to A. salina (DL₅₀ = 486.27 µg/mL) and toxic to C. quinquefasciatus (DL₅₀ = 20.92 µg/mL). The AG was 23 times high toxic for C. quinquefasciatus when compared to A. salina, which indicates selectivity and encourages further studies regarding the insecticidal activity. The work results are promising and have great relevance since this is the first report of the antioxidant and larvicidal activities of samples from T. stans seeds.

BANKING MEMBERS:
Presidente - 1540495 - LUCIANA ALVES RODRIGUES DOS SANTOS LIMA
Externa à Instituição - MELISSA GRAZIELLE MORAIS - UNA
Externo à Instituição - MAIRON CESAR COIMBRA - UFSJ