Banca de QUALIFICAÇÃO: ALINE THAYNARA DE MOURA COELHO

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : ALINE THAYNARA DE MOURA COELHO
DATE: 08/08/2022
TIME: 14:00
LOCAL: remoto
TITLE:

MELATONIN AND SODIUM VALPROATE IN PREGNANCY: EFFECTS ON THE ANTIOXIDANT SYSTEM AND HEPATIC FUNCTION OF DESCENDANTS

KEY WORDS:

melatonin, pinealectomy, sodium valproate, liver function, oxidative stress.

PAGES: 54
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:

Melatonin is a hormone acting in organization of sleep as well as in fetal development. Low concentrations of this hormone in pregnancy seems to cause harms to the pregnant woman, the fetus and the offsprings. In contrast of it certain exogenous molecules such as sodium valproate may cause risks to organism development. Valproate is used in treatment of epilepsy and bipolar disorder tough it is known teratogenic effects when used in pregnancy. This study aimed to evaluate the maternal prenatal exposure to melatonin and sodium valproate to adolescent offsprings function and antioxidant system of the liver. First of all, levels of proteins, glucose, triglycerides, cholesterol and the Na+,K+-ATPase activity were determined in liver fractions, as an initial analysis of liver function. Then part of hepatocytes antioxidant system integrity was evaluated by measuring GSH, MDA and H2O2. Results showed no changes in Na+,K+-ATPase activity and macronutrient content in groups whose mothers were exposed to valproate or melatonin compared to the control. Likewise no significant changes were observed in the content of GSH, MDA and H2O2. These results suggest that the liver function and antioxidant system in adolescent rats are not influenced by maternal prenatal exposure to sodium valproate or melatonin. These results can be due to a specificity of the liver tissue since studies under conditions similar to those applied here showed significant changes in the analyzed markers in other organs. Other evaluations will be carried out but in general lines this study strengthens the evidence about a non heavily explored topic in the scientific community so far which is the role of maternal exposure to melatonin and valproate in development of the offsprings liver – an essential organ for organism functions.

BANKING MEMBERS:
Presidente - 1526269 - LEANDRO AUGUSTO DE OLIVEIRA BARBOSA
Interno - 1716137 - HELIO BATISTA DOS SANTOS
Externa ao Programa - 1692875 - VALERIA ERNESTANIA CHAVES