Banca de QUALIFICAÇÃO: LORENA RASPANTE DE SOUSA

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : LORENA RASPANTE DE SOUSA
DATE: 17/02/2023
TIME: 13:30
LOCAL: Campus Centro Oeste D. Lindu - UFSJ
TITLE:

Evaluation of the antineoplastic potential of synthetic compounds derived from lapachol and lawsone, isolated and in combination  with TMZ, on glioblastoma lineages.

KEY WORDS:

Glioblastoma, drug combination, cell culture, selectivity, TMZ

PAGES: 21
BIG AREA: Ciências Biológicas
AREA: Bioquímica
SUBÁREA: Biologia Molecular
SUMMARY:

Glioblastoma (GBM) is the most frequent primary brain tumor, uncurable, and with a low survival rate. The triad surgical resection, radiotherapy, and chemotherapy with temozolomide  (TMZ) are limited and no new therapy significantly improves the survival rate of patients with  this disease. So, searching for more effective and specific drugs is crucial, especially those  capable of penetrating the blood-brain barrier (BBB). Due to tumor heterogeneity, the  combination of drugs may be the best way to approach this disease. Previous studies have  shown that the combination of TMZ with some natural agents enhances its effectiveness  against GBM. Accordingly, this study investigated the antitumor effects of 10  naphthoquinones derived from Lapachol and Lawsone, alone and in combination with TMZ,  against GBM cell lines. Three compounds A3, A4, and A6 were cytotoxic to all GBM cell lines  tested, but only A4 was more selective than TMZ for all lineages, capable of preventing cell  migration, and predicted to be able to cross BBB. So, A4 was selected for the combinatory  analysis with TMZ. The combinations C1 for U87 (25µM A4 + 122.7 µM TMZ) and C1 for  GAMG (8.4µM A4 + 5µM TMZ) showed best selectivity.

BANKING MEMBERS:
Presidente - 1680611 - ROSY IARA MACIEL DE AZAMBUJA RIBEIRO
Externa ao Programa - 1006938 - LUCIANA XAVIER PEREIRA
Externa à Instituição - IZABELA NATALIA FARIA GOMES - SS284