Banca de QUALIFICAÇÃO: MARINA MARQUES LOPES DE MORAIS TOLEDO

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : MARINA MARQUES LOPES DE MORAIS TOLEDO
DATE: 09/08/2023
TIME: 14:00
LOCAL: https://meet.google.com/byy-inja-mfk
TITLE:

Evaluation of the influence of probiotic supplementation on oxidative parameters and metabolism in male Wistar rats induced to mild stress.

KEY WORDS:

probiotics, depression, oxidative stress, liver function, heart, hippocampus

PAGES: 100
BIG AREA: Ciências Biológicas
AREA: Bioquímica
SUMMARY:

The human microbiota plays an important role in human health. individual and, consequently, in the development of diseases. Studies point to the ability of the microbiota to influence the nervous system center, specifically promoting a two-way relationship between the brain and the intestine, having an impact on the installation and progression of diseases neuropsychiatric. Depression is a debilitating neuropsychiatric disorder, and the association between intestinal microbiota and depression has been object of many studies carried out in recent years. The mechanism that connects to depression to changes in the microbiota is explained through the microbiota- gut-brain, which includes the immune, endocrine, and autonomic systems, and molecules originating from the microbiota that participate in the regulation of these interactions. Furthermore, research suggests that oxidative mechanisms seem to be a common pathogenic factor in psychiatric disorders, that these damages are not restricted to the brain, and may have consequences systemic. Due to recent evidence implicating the gut- brain in depression, with occurrence of oxidative stress and inflammation, has there has been interest in developing treatments, namely probiotics, which aimed at restoring the intestinal microbiota. Probiotics are preparations microorganisms which, when administered, improve the balance intestinal microbial activity and modulate the composition of the intestinal microbiome benefiting the host. It is still unclear whether probiotics are able to promote decrease or protection against the systemic effects of depression, as well as liver damage associated with the development of metabolic rate arising from the establishment of the depressive condition. In this way, the The proposed study seeks to assess the safety of administering a new probiotic and its potential use as a psychobiotic through the modulation of markers of oxidative stress in hippocampus, heart and liver of animals and also liver function parameters.

BANKING MEMBERS:
Presidente - 1716846 - VANESSA FARIA CORTES
Interno - 1757978 - DANIEL BONOTO GONCALVES
Externo ao Programa - 3295713 - ISRAEL JOSE PEREIRA GARCIA
Externo à Instituição - LEONARDO VAZQUEZ
Externo à Instituição - JÚLIO ALBERTO MIGNACO