Banca de DEFESA: GEISA CRISTINA DA SILVA ALVES

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : GEISA CRISTINA DA SILVA ALVES
DATE: 06/07/2022
TIME: 08:00
LOCAL: Videoconferência
TITLE:

Pharmacokinetic and pharmacodynamic (PK/PD) profile of piperacillin in critically ill patients from an Intensive Care Unit of a medium-sized hospital in the Midwest of Minas Gerais.

KEY WORDS:

Pharmacokinetics/Pharmacodynamics. Piperacillin. Critical Patients. Intensive care unit. Pseudomonas aeruginosa. Bacterial resistance.

PAGES: 108
BIG AREA: Ciências da Saúde
AREA: Saúde Coletiva
SUMMARY:

Introduction: Extended spectrum antimicrobial dosing strategies to reach the
therapeutic target, especially for bacterial infections in critically ill patients, remains
a challenge. Objective: To evaluate the pharmacokinetics (PK) and
pharmacodynamics (PD) of piperacillin in critically ill patients in an Intensive Care
Unit (ICU) in a medium-sized hospital in the Midwest of Minas Gerais. Method: This
is a cross-sectional study, where the outcome of reaching the therapeutic target was
evaluated in critically ill patients allocated in an ICU, using piperacillin. Individuals
with indication of piperacillin use were recruited during a 12-month period. 03 blood
samples were collected on the fifth day of treatment with piperacillin with two-hour
intervals between each sample, and the antimicrobial in blood plasma was
quantified by high performance liquid chromatography (HPLC). Reaching the
therapeutic target was measured using the effectiveness parameter set at 50% and
100% of the time free concentrations were above the minimum inhibitory
concentration (%fT>MIC) for a MIC of 8 mg/L. Clinical severity outcomes of patients
included at 5, 7, 14, 28 and 30 days of ICU treatment with piperacillin were also
evaluated. Data were expressed as medians, interquartile (IQ25%-75%), minimum
and maximum values. Results: We included 30 patients, adults, aged 71 years
(median: 61-78/IQ25%-75%), with a predominance of females 53% (n=16). Using
12g of piperacillin per day, infusion time of approximately 30 minutes, with intervals
between doses of 8/8h, it was observed that 50% (n=15) of patients reached
50%fT>MIC, and 33% (n=15) =10) 100%fT>MIC. P.aeruginosa was the most
prevalent bacterium, present in 20% (n=6) of the isolates from biological samples
from the patients included. Conclusion: Reaching the therapeutic target in critically
ill patients using empiric piperacillin is still quite controversial, and we believe that
further studies are needed in this area.

BANKING MEMBERS:
Externa à Instituição - KARIN JANNET VERA LOPEZ - UCSM - Perú
Externa ao Programa - 1741307 - ADRIANA CRISTINA SOARES DE SOUZA
Presidente - 1039964 - ANDRE DE OLIVEIRA BALDONI
Externa ao Programa - 1971548 - CRISTINA SANCHES
Externo à Instituição - DANILO CESAR GALINDO BEDOR - UFPE
Interna - 1742677 - JAQUELINE MARIA SIQUEIRA FERREIRA