Banca de DEFESA: VICTOR ANTONIO FERREIRA FREIRE

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : VICTOR ANTONIO FERREIRA FREIRE
DATE: 26/08/2022
TIME: 13:30
LOCAL: Videoconferência
TITLE:

ASSESSMENT OF OXIDATIVE STRESS IN PREECLAMPSIA: SYSTEMATIC REVIEW AND META-ANALYSIS

KEY WORDS:

Antioxidants, biomarkers, placenta.

PAGES: 115
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:

The preeclampsia is a hypertensive syndrome of pregnancy responsible by high rate of complications and morbimortality maternal and fetal. The understand about the role of inflammation, imbalance of anti-angiogenic factors and oxidative stress in the development of preeclampsia brought advance for the comprehension of its pathophysiology, but also showed different profiles between early and late PE. Therefore, this study search to review the oxidative stress profile in the PE subtypes and evaluate which markers are altered in blood and placental tissue. In September of 2021, a search was conducted in different databases such as MEDLINE, EMBASE, LILACS, and Web of Science without restriction of year and language of publication. The quality of the studies was evaluated by Newcastle-Ottawa scale and Joanna Briggs Institute for analytical Cross-Sectional Studies. From the 12,080 screened records, 62 were finally included in the systematic review. The markers of stress oxidative evaluated were those related to damage and antioxidant activity, such as malondialdehyde (MDA), lipid peroxides, hydrogen peroxide, oxide nitric (NO), advanced oxidation protein products, carbonylated protein, 8-hydroxy-2′-deoxyguanosine, total oxidant status, total antioxidant capacity (TAC), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione S-transferase and free glutathione. Meta-analysis revealed that the MDA levels in the blood and placenta were significantly increased in the combined PE, just as in mild and severe PE. Pregnant women with mild and severe PE were identified with low serum levels of NO. Markers related to TAC and enzymatic activity, including GPx, CAT, and SOD in mild PE, were significantly lower in the blood of pregnant women with PE. The results demonstrated that oxidative stress is related to the pathophysiology of PE, through increased lipid peroxidation, reduction of NO levels and the antioxidant capacity, like lower enzymatic activity of GPx, CAT, and SOD in PE. In addition, altered levels of MDA in placenta and blood show that placental changes have repercussions on the clinical syndrome.  

BANKING MEMBERS:
Externo à Instituição - CRYSTIAN BITENCOURT SOARES DE OLIVEIRA - UNOESTE
Externa à Instituição - ESTELA MARIS ANDRADE FORELL BEVILACQUA - USP
Presidente - 1544462 - HERICA DE LIMA SANTOS
Interna - 1699263 - MELINA DE BARROS PINHEIRO INACIO