Banca de DEFESA: DÉBORA SOARES DA SILVA MAIA

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : DÉBORA SOARES DA SILVA MAIA
DATE: 06/11/2020
TIME: 14:00
LOCAL: Videoconferência
TITLE:

Evaluation of biological activities of Annonaceae species

KEY WORDS:

Annona, Duguetia, Culex quinquefasciatus, Artemia salina, cytotoxic.

PAGES: 128
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:

Plant species of the Annonaceae family have stood out for having a great chemical diversity resulting in different biological and pharmacological activities, which justifies the continued exploration of this family in search of natural substances with application in various areas of human interest. In the present work the species Annona mucosa, A. muricata, A. nutans, Duguetia furfuracea and D. lanceolata were investigated for larvicidal activity on Culex quinquefasciatus and Artemia salina, and only D. lanceolata was evaluated for their cytotoxic potential. Hydroethanolic extracts and chloroform, hexane, ethyl acetate and butanolic fractions were obtained from the leaves of the five species studied. The alkaloid extracts of the leaves and underground stem bark and the petroleum ether extract of the underground parts of D. furfuracea were also obtained. In addition to the essential oils of D. lanceolata leaves and D. furfuracea leaves and underground parts. All plant derivatives were tested for larvicidal activity on C. quinquefasciatus larvae and toxicity on A. salina. It was also tested the cytotoxic activity of the essential oil of D. lanceolata leaves and its fractions on U251 cells. All species tested showed toxicity on A. salina. The crude hydroethanolic extracts of A. mucosa and A. muricata, as well as their chloroform and hexane fractions, the petroleum ether extracts and all the essential oils tested were active on C. quinquefasciatus larvae. It was possible to limit a range of activity in A. salina, which has one corresponding to the larvicidal test on C. quinquefasciatus, so the A. salina test can be used as a model for pre-evaluation of larvicidal activity. D. lanceolata essential oil and some fractions were cytotoxic against the U251 human glioblastoma lineage presenting potential for new antitumor agents.

BANKING MEMBERS:
Externa à Instituição - FERNANDA DE OLIVEIRA BUSTAMANTE - UEMG
Externo à Instituição - ALYSSON RODRIGO FONSECA E SILVA - UEMG
Interno - 1544480 - EDUARDO SERGIO DA SILVA
Presidente - 434006 - JOAO MAXIMO DE SIQUEIRA
Externa ao Programa - 1540495 - LUCIANA ALVES RODRIGUES DOS SANTOS LIMA