Banca de DEFESA: LETICIA GONCALVES RESENDE FERREIRA

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : LETICIA GONCALVES RESENDE FERREIRA
DATE: 16/12/2022
TIME: 09:00
LOCAL: Videoconferência
TITLE:

THROMBIN GENERATION AS A MARKER OF CARDIOVASCULAR EVENTS AND MORTALITY

KEY WORDS:

Thrombin generation assay, cardiovascular diseases, cardiovascular mortality, all-cause mortality.

PAGES: 82
BIG AREA: Ciências da Saúde
AREA: Saúde Coletiva
SUMMARY:

The thrombin generation assay (TGA) is a laboratory method that allows the global evaluation of hemostasis. The association between thrombin generation and cardiovascular events, especially acute myocardial infarction (AMI) and stroke, all-cause and cardiovascular mortality is still poorly investigated and the results are often inconsistent. Considering that cardiovascular diseases (CVDs) present in their pathophysiology a strong interaction between inflammation and hemostasis, thrombin, a key enzyme in the clotting process can be thought as a possible biomarker of cardiovascular risk. At the present work we review and summarize the results of the main studies that evaluated whether TGA parameters were associated with cardiovascular events, cardiovascular mortality and all-cause mortality and also evaluated whether TGA is associated with all-cause mortality in a prospective cohort of Brazilian adults.

Methods: The article search was performed between January and June 2022. The evaluation of association between TGA and all-cause mortality was performed with 2,588 participants at the baseline of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). TGA parameters lagtime, time-to-peak, peak, Endogenous Thrombin Potential (ETP) and normalized ETP (nETP) were evaluated according to the reference interval (RI). The association between TGA and all-cause mortality was estimated by Cox regression and adjusted for confounders.

Results: We included 13 studies in our review article. At second article, the mean follow-up time was 6.6± 2.7 years and 85 deaths occurred during the follow-up period. After adjustment, time-to-peak values above the RI at low and high tissue factor (TF) concentrations were associated with a higher risk of death [HR=2.45 (1.17-5.13) and HR=2.24 (1.02-4.93), respectively] and nETP and peak values below the RI at high TF concentration were associated with a higher risk of all-cause mortality [HR=3.85 (1.39-10.68) and HR=2.56 (1.17-5.61), respectively].

Conclusions: TGA can be a potentially interesting assay, also in subjects with CVDs, but its usefulness for clinical translation needs better understanding of the underlying determinants of thrombin generation. 

BANKING MEMBERS:
Externa à Instituição - SUELY MEIRELES REZENDE - UFMG
Interna - 1821418 - CAMILA TEIXEIRA VAZ
Presidente - 1581667 - DANYELLE ROMANA ALVES RIOS
Externa à Instituição - GABRIELA MIANA DE MATTOS PAIXÃO - UFMG
Externa à Instituição - RITA CAROLINA FIGUEIREDO DUARTE - SES-MG
Interna - 2059540 - ROBERTA CARVALHO DE FIGUEIREDO