Banca de DEFESA: HEBER PAULINO PENA

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : HEBER PAULINO PENA
DATE: 17/11/2020
TIME: 09:00
LOCAL: Videoconferência
TITLE:

ASSOCIATION BETWEEN THE HISTOPATHOLOGICAL FINDINGS AND THE DIAGNOSIS OF TEGUMENTARY LEISHMANIOSIS, CONFIRMED BY PCR, IN AN ENDEMIC REGION OF THE INTERIOR OF BRAZIL: A CROSS-SECTION STUDY

KEY WORDS:

 

Cutaneous leishmaniasis, diagnosis, PCR, histopathology.

PAGES: 105
BIG AREA: Ciências da Saúde
AREA: Saúde Coletiva
SUMMARY:

Introduction: Leishmaniasis is a disease that presents itself from small skin lesions to visceral disorders that can evolve to death. Its diagnosis is still a difficult task. Objectives: To evaluate the association of histopathological criteria with the results of polymerase chain reaction (PCR) of clinically suspected cases of cutaneous leishmaniasis (CL). Methods: An observational, cross-sectional, and retrospective study that evaluated, by PCR and histological examination, skin samples received during 9 years of clinically suspected cases of CL. Results: The results demonstrate that the evaluated histological variables did not show statistical significance with the result of the PCR when considered individually: ulceration (P = 0.231), epidermal hyperplasia (P = 0.595), hyperkeratosis (P = 0.103), presence of granuloma (P = 0.280), neutrophils (P = 0.475), histiocytes (P = 0.241), lymphocytes (0.543), plasmocytes (0.291), and necrosis (0.746). Limitations: Cases from a single institution with a small number of negative ones in PCR were analyzed. Conclusions: The data from the present study highlight the high specificity of microscopy analysis with 100% agreement with the PCR result for clinically suspected cases in an endemic Brazilian region. However, a histopathological finding in isolation cannot predict PCR positive results.

 

BANKING MEMBERS:
Externo à Instituição - EDUARDO DE CASTRO FERREIRA - FIOCRUZ
Externa à Instituição - SOLANGE CORREA GARCIA PIRES D’AVILLA - FAMERP
Presidente - 1544480 - EDUARDO SERGIO DA SILVA
Interno - 066.589.338-80 - LUIS MARCELO ARANHA CAMARGO - USP
Externo ao Programa - 2875448 - RALPH GRUPPI THOME