Banca de DEFESA: DAYANE HELEN FERREIRA SILVA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : DAYANE HELEN FERREIRA SILVA
DATE: 23/02/2023
TIME: 13:30
LOCAL: Videoconferência
TITLE:

ORAL MANIFESTATIONS IN PATIENTS WITH SICKLE CELL DISEASE: a systematic review and meta-analysis

KEY WORDS:

Sickle Cell Disease, oral manifestations, oral health.

PAGES: 62
BIG AREA: Ciências da Saúde
AREA: Saúde Coletiva
SUMMARY:

Sickle cell disease (SCD) is one of the most prevalent hemoglobinopathies and results from the replacement of normal hemoglobin (Hb A) by hemoglobin S (HbS), in a homozygous or heterozygous state with other abnormal hemoglobins. The Hb S variant results from the substitution of glutamic acid for valine at position 6 of the β polypeptide chain. This alteration causes profound changes in the stability and solubility of the Hb molecule, favoring the sickling phenomenon and causing serious clinical consequences. The pathophysiology of the disease involves several complications, such as intense hemolytic anemia, and any tissue or organ can be affected. The Sickle cell disease (SCD) is one of the most prevalent hemoglobinopathies and results from the replacement of normal hemoglobin (Hb A) with hemoglobin S (HbS), in a homozygous or heterozygous state with other abnormal hemoglobins. Variant Hb S results from the substitution of glutamic acid for valine at position 6 of the β-polypeptide chain. This alteration causes profound changes in the stability and solubility of the Hb molecule favoring the phenomenon of sickling, causing severe clinical consequences. The pathophysiology of the disease involves several complications, such as intense hemolytic anemia, and any tissue or organ can be affected. The same pathological effects of DF on the connective tissues of different parts of the body - kidneys, liver, spleen, lungs and heart - have occurred in dental tissues and the oral cavity in general. In this context, the aim of this systematic review was to identify and analyze the prevalence of oral manifestations found in patients with DF. The electronic databases consulted were MEDLINE (via Pubmed), EMBASE, Web of Science, Latin American and Caribbean Literature on Health Sciences (LILACS). After analysis of a total of 16 included studies (n=3852), the presence of caries, malocclusion, and gingival bleeding were the most commonly reported oral changes. The prevalence of combined caries was 0.72 (95% CI: 0.54- 0.91), malocclusion 0.86 (95% CI: 0.43-1.28), and gingival bleeding 0.62 (95 % CI: 0.40-0.84). Knowledge about this may help to fill an existing gap in the scientific literature and above all guide dental surgeons in the approach and care of patients with FD, reducing iatrogenesis and improving care to this group.

BANKING MEMBERS:
Externo à Instituição - CRYSTIAN BITENCOURT SOARES DE OLIVEIRA - UNOESTE
Externa à Instituição - MARIA DAS GRACAS CARVALHO - UFMG
Presidente - 1699263 - MELINA DE BARROS PINHEIRO INACIO
Externa à Instituição - RENATA DE CASTRO MARTINS - UFMG