Banca de DEFESA: ANA PAULA SILVA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : ANA PAULA SILVA
DATE: 11/08/2023
TIME: 14:00
LOCAL: Videoconferência
TITLE:

OBESITY AND COMMUNITY-ACQUIRED BACTERIAL PNEUMONIA: A SYSTEMATIC REVIEW AND META-ANALYSIS


KEY WORDS:
Community-acquired pneumonia; Bacterium; Body mass index; Obesity; Prognosis; Mortality; Infection.

PAGES: 38
BIG AREA: Ciências da Saúde
AREA: Saúde Coletiva
SUMMARY:
Introduction: Obesity is associated with comorbidities that considerably increase the risk of
acquiring infections, especially community-acquired pneumonia (CAP) caused by bacteria.
Paradoxically, some studies indicate that excess adiposity may be directly related to better
survival in patients hospitalized with bacterial pneumonia. Objectives: In this context, the
objective of this study was to determine the real impact of body mass index (BMI) on mortality
from bacterial CAP through a systematic review and meta-analysis. Methods: Studies were
searched in five databases. After selection according to the established eligibility criteria, the
selected articles were read in full and the variables of interest were extracted. The 30-day and
90-day bacterial CAP mortality were used to estimate the pooled odds ratio using the Mantel
Haenszel statistical method in the Review Manager (RevMan)® 5.3 software. The heterogeneity
of the primary data was analyzed using the I2 test. Results: Nine studies, which together
included 25,398 patients diagnosed with bacterial CAP (10,800 controls, 7,486 overweight and
7,112 obese), were selected for this systematic review. Patients with normal weight have a
higher risk of 30-day mortality from bacterial CAP compared to overweight patients (odds
ratio:1.28; IC (1.15,1.42); p-value <0.00001; I2=0%) and obese patients (odds ratio: 1.83; IC
(1.62,2.07), p-value <0.00001; I2=0%). Similarly, in the meta-analysis of the 90-day lethality,
normal-weight patients also had a worse prognosis when compared to obese patients (odds
ratio: 1.79; IC (1.61,1.98); p-value <0.00001; I2=0%). Conclusion: Obesity acts as a
protective factor against death from bacterial community-acquired pneumonia (CAP).

BANKING MEMBERS:
Presidente - 319693 - JOEL ALVES LAMOUNIER
Externa ao Programa - 1680498 - MARCIA CHRISTINA CAETANO ROMANO
Externo à Instituição - VINICIUS DE OLIVEIRA DAMASCENO - UNIFA
Notícia cadastrada em: 03/08/2023 10:57
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