Banca de QUALIFICAÇÃO: TALUANE VÍVIAN GOMES ALVES

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : TALUANE VÍVIAN GOMES ALVES
DATE: 01/09/2023
TIME: 09:00
LOCAL: Videoconferência
TITLE:

Inflammatory hematological indices and overall mortality in patients undergoing peritoneal dialysis

KEY WORDS:

Biomarkers, Peritoneal dialysis, All-cause mortality.

PAGES: 63
BIG AREA: Ciências da Saúde
AREA: Saúde Coletiva
SUMMARY:

Although chronic kidney disease (CKD) treatments have achieved improvements over time, chronic inflammation and oxidative stress, present in these patients, accelerate the morbidity and mortality process. Chronic inflammation indicators can serve as a clinical tool for risk detection and guide decision-making in disease management. Peritonitis is the main cause of PD failure and transfer to hemodialysis (HD). With the aim of increasing survival, it is necessary to act on the risk factors for transferring to HD to provide better support for patients treated on peritoneal dialysis (PD). In routine follow-up, PD patients need cheaper, more convenient and effective measurements for risk and mortality stratification. New inflammatory hematological indices have shown promise in predicting mortality in patients undergoing PD. Thus, the present research aims to evaluate the association of hematological inflammatory indices with all-cause mortality and transfer to HD in patients undergoing PD. Methods: A prospective cohort was performed with 43 patients undergoing PD for 18 months. Blood samples were collected and analyzes of the patients' charts were carried out. The following hematological indices were calculated: Neutrophil-Lymphocyte Ratio (RN), Platelet-Lymphocyte Ratio (PLR), Derived Neutrophil-Lymphocyte Ratio (Drnl), Monocyte-Lymphocyte Ratio (RML), Lymphocyte-Monocyte Ratio (MLR), Aggregate Index of Systemic Inflammation (AISI), Systemic Inflammatory Index (SII) and the Systemic Inflammatory Response Index (SIRI). Results: For AISI and SIRI, for each peritonitis diagnosed, the risk of death or transfer to hemodialysis was 1.75 (95% CI: 1.00-3.06) and 1.71 (95% CI: 1.01-2, 92) times higher compared to patients without peritonitis, respectively. AISI did not impact the risk of occurrence of the outcomes (HR: 1; 95% CI: 1.00-1.01) . For SIRI, at each increase of one unit, the risk of death or transfer to hemodialysis increases 4.4 times (95% CI: 1.29-15.07). Conclusion: The number of peritonitis and the SIRI were associated with all-cause mortality in PD patients.

BANKING MEMBERS:
Externa à Instituição - PATRÍCIA NESSRALLA ALPOIM - UFMG
Externa à Instituição - ANA PAULA LUCAS MOTA - UFMG
Presidente - 1581667 - DANYELLE ROMANA ALVES RIOS