Banca de DEFESA: CEZENÁRIO GONÇALVES CAMPOS

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : CEZENÁRIO GONÇALVES CAMPOS
DATE: 13/12/2023
TIME: 14:00
LOCAL: Videoconferência
TITLE:

PROFILE CLINICAL AND EPIDEMIOLOGICAL OF COVID-19 INFECTION, MILD AND MODERATE, IN CHILDREN AND ADOLESCENTS


KEY WORDS:
Child health. Adolescent health. Health profile. COVID-19.

PAGES: 99
BIG AREA: Ciências da Saúde
AREA: Saúde Coletiva
SUMMARY:
Introduction: Coronavirus Disease 2019 (COVID-19), a disease discovered in December 2019
in China, was and still is a public health issue. Four years after the first reports of the disease in
humans, the clinical, epidemiological, demographic characteristics and comorbidities
associated with the infection, mild and moderate forms, in the pediatric and adolescent
population, have not been analyzed in several national and international regions. In the
literature, the severe and critical forms have been widely discussed, however, information
regarding less severe cases is scarce. Studies with children and adolescents infected with
COVID-19 with mild and moderate conditions are important, as they provide indicators for
improving public policies for this age group in primary health care and enable the development
of care protocols to combat and prevent the disease. Presentation of the objectives, methods,
results and final considerations of the articles: The products of this thesis are two articles.
The first consists of a systematic review of observational studies with the aim of verifying the
clinical characteristics, associated comorbidities and outcomes of COVID-19 in adolescents. A
search was carried out for articles published between 2020 and 2022 in the databases of the
United States National Library of Medicine (PubMed), Virtual Health Library (VHL), Science
Direct, Web of Science and Scopus. 13 articles were included in the review. The prevalence of
COVID-19 was found to be 25%. Mild cases were predominant. The symptoms of fever, cough,
headache, olfactory disorders, nasal congestion and taste disorders were common in adolescents
infected with COVID-19. Fever and cough were proportionally higher in hospitalized cases, at
81 and 68%, respectively. Dyspnea (OR 6.3; 95%CI 2.8–14.3), fever (OR 3.8; 95%CI 2.0–7.4)
and cough (OR 3.4; 95%CI 2.0–6,0) were associated with severe cases. Among the participants,
28% required intensive care and 38% mechanical ventilation. The pre-existence of comorbidity
increased the risk of hospitalization and death. Severe cases were associated with the risk of
death (relative risk — RR 4.6; 95%CI 2.8–7.5). Black, brown and indigenous races/colors and
residents of poorer regions were at risk. The review allowed us to understand the profile of the
disease and could favor the development of public policies, in addition to contributing to the
current literature in the field of adolescent health. The second article aimed to analyze the
clinical, epidemiological, demographic profile and associated comorbidities of children and
adolescents infected by COVID-19, with mild and moderate conditions. This is a cross-
sectional study and analysis of secondary data. Clinical, epidemiological, demographic data and
associated comorbidities were collected from suspected cases and confirmed cases of COVID-
19 in children and adolescents reported in the e-SUS Notifica system, from March 13, 2020 to 
March 31, 2022, from a municipality in the Central-West region of Minas Gerais. 21,949
suspected cases of COVID-19 were reported in children and adolescents. Respectively, 2,602
cases were positive for the disease, 835 children and 1,767 adolescents, according to laboratory
tests, corresponding to a prevalence of 8.6 infected children for every 100 cases reported in the
age group from zero to nine years old and 14.4 infected adolescents for every 100 cases reported
in the age group of 10 to 19 years. In the study, we identified that children with symptoms of
headache (OR 1.5; 95%CI 1.2–1.8) and taste disorders (OR 2.7; 95%CI 1.7–4,2), in addition to
those with diabetes (OR 4.7; 95%CI 1.6–13.6) and adolescents with headache symptoms (OR
1.4; 95%CI 1.2–1.6), fever (OR 1.2; 95%CI 1.1–1.4) and olfactory disorders (OR 2.3; 95%CI
1.9–2.7) had higher odds of being diagnosed with COVID-19. The chance of COVID-19 is also
higher in the group of children between five and nine years old compared to the age group from
zero to less than one year old (OR 1.4; 95%CI 1.2–1.7) and from one to four years (OR 1.6;
95%CI 1.3–1.8). Children who had a sore throat (OR 0.7; 95%CI 0.6–0.9), cough (OR 0.5; 95%
CI 0.4–0.6), runny nose (OR 0.7; 95%CI 0.6–0.8) and adolescents with symptoms of sore throat
(OR 0.7; 95%CI 0.7–0.8) and runny nose (OR 0.8; 95%CI 0.7–0.9) were less likely to be
diagnosed with COVID-19. The study found that age between five and nine years, headache
symptoms, taste disorders and diabetes are associated with the diagnosis of COVID-19 in the
child population. In addition to demonstrating that headache, fever and olfactory disorders were
symptoms associated with COVID-19 infection in the adolescent population. In this context,
knowing the profile of children and adolescents with mild and moderate COVID-19 infection
contributes to the development of care protocols for the diagnosis, treatment and monitoring of
the disease in primary health care. Furthermore, it is suggested that public policies be directed
towards surveillance of respiratory-transmitted diseases in primary health care.

BANKING MEMBERS:
Externo ao Programa - 1264193 - ALISSON ARAUJO
Presidente - 319693 - JOEL ALVES LAMOUNIER
Externo à Instituição - JOSÉ VÍTOR VIEIRA SALGADO - UEMG
Interna - 1945166 - MAIRA DE CASTRO LIMA
Externa ao Programa - 1680498 - MARCIA CHRISTINA CAETANO ROMANO
Externa à Instituição - THALYTA CRISTINA MANSANO SCHLOSSER - USP
Notícia cadastrada em: 28/11/2023 16:05
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