Banca de DEFESA: ISABELLA VIANA GOMES SCHETTINI

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : ISABELLA VIANA GOMES SCHETTINI
DATE: 18/12/2023
TIME: 14:00
LOCAL: Videoconferência
TITLE:

USE OF DIFFERENT CLASSES OF ANTIHYPERTENSIVE MEDICINES AND ARTERIAL RIGIDITY IN THE LONGITUDINAL STUDY OF ADULT HEALTH BRAZIL (ELSA-BRASIL)


KEY WORDS:
Arterial Stiffness, pulse wave velocity, use of antihypertensives, arterial hypertension.

PAGES: 80
BIG AREA: Ciências da Saúde
AREA: Saúde Coletiva
SUMMARY:
INTRODUCTION: Arterial Stiffness (AR) in patients with hypertension has been
associated with a greater risk of cardiovascular disease (CVD), the effect of controlling
Blood Pressure (BP) and specific treatment with some classes of antihypertensive drugs
appears to have benefits for FROG. Our objectives were: (1) to carry out a narrative
review of the results of the main studies that evaluated the association between different
classes of antihypertensive drugs and RA and (2) to evaluate the longitudinal
association between BP control and the specific use of classes of antihypertensives with
RAl in participants without CVD at the beginning of the study. METHODS: Article 1:
The search for articles was carried out between May and June 2022. Article 2: 1830
participants from the Longitudinal Study of Adult Health (ELSA-Brazil) were included.
AR was assessed by Pulse Wave Velocity (PWV) and Pulse Pressure (PP) at baseline
and repeated after approximately 9 years of follow-up. Associations between AR, BP
control and the use of antihypertensive classes (in the population with controlled BP) at
baseline were investigated using linear mixed-effects models. RESULTS: Article 1:
Clinical trials raised the possibility that drugs such as CCB, ACEI and ARB may have
effects on arterial stiffness independent of BP reduction, whereas observational studies
are quite scarce and do not show a superior effect on AR due to the use of a specific
class of medication. Article 2: BP control was associated with a better PWV and PP
trajectory (p<0.001). Among participants with controlled BP, the use of CCB and CCB
plus ARB were associated with worse PWV (p<0.05), compared to not using this class
and this combination respectively. CONCLUSION: BP control regardless of the
medication used is associated with better AR. Among participants with controlled BP,
the use of CCB and CCB plus ARB appears to be worse for the trajectory of PWV in
individuals with arterial hypertension without CVD. More studies are needed to assess
whether this effect offers a better prognosis for patients with hypertension and whether
it can serve as a basis to guide the treatment of these patients.

BANKING MEMBERS:
Externo à Instituição - ITAMAR DE SOUZA SANTOS - USP
Externa à Instituição - LUISA CAMPOS CALDEIRA BRANT - UFMG
Presidente - 2059540 - ROBERTA CARVALHO DE FIGUEIREDO
Interno - 1716637 - TARCISIO LAERTE GONTIJO
Externa à Instituição - THAYS SANTOS MENDONCA - UNA
Notícia cadastrada em: 01/12/2023 12:39
SIGAA | NTInf - Núcleo de Tecnologia da Informação - | Copyright © 2006-2024 - UFSJ - sigaa05.ufsj.edu.br.sigaa05