Banca de DEFESA: TALUANE VÍVIAN GOMES ALVES

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : TALUANE VÍVIAN GOMES ALVES
DATE: 16/02/2024
TIME: 09:00
LOCAL: Videoconferência
TITLE:

Inflammatory hematological indices and overall mortality in patients undergoing peritoneal dialysis


KEY WORDS:

Biomarkers, Peritoneal dialysis, All-cause mortality, Cox model to competitive risks.


PAGES: 65
BIG AREA: Ciências da Saúde
AREA: Saúde Coletiva
SUMMARY:
Introduction: Peritoneal dialysis (PD) is one of the renal replacement therapy options in which
the peritoneum is used to filter blood. Peritonitis is the main cause of PD failure and transfer to
hemodialysis (HD). Indicators of chronic inflammation can serve as a clinical tool for detecting
risk and guiding decision-making in disease management. In routine follow-up, PD patients
need cheaper, more convenient and effective guidance for risk and mortality stratification. New
hematological indices hold promise for predicting mortality in patients undergoing PD.
Therefore, the present study aims to evaluate the association of hematological indices with all
cause mortality and transfer to HD in patients undergoing PD. Methods: A prospective cohort
was carried out with 43 patients undergoing PD followed for 18 months. Hematological indices
were calculated from the blood count data found in the patients' records, namely: Neutrophil
Lymphocyte Ratio (RN), Platelet-Lymphocyte Ratio (RPL), Derived Neutrophil-Lymphocyte
Ratio (dRNL), Monocyte-Lymphocyte Ratio ( RML), Aggregate Systemic Inflammation Index
(AISI), Systemic Inflammatory Index (SII) and the Systemic Inflammatory Response Index
(SIRI). These indices were categorized by the median. Patient survival was estimated using the
Kaplan Meier method and survival curves were compared using the Logrank test. The Cox
model for competing risks was used to evaluate the influence of survival rates. Results: In
survival estimates, only LMR, AISI and SII were statistically significant at the 5% level, with
a higher survival rate for AISI≤149.61 (p=0.01) and SII ≤ 722.80 (p= 0.02) . In the Cox
regression analysis, only AISI and SII maintained a statistically significant association after
adjustment. For every 1-unit increase in AISI, the risk of death or transfer to HD increased 9.38
times (p=0.01). For every increase of 1 unit in SII, the risk of death or transfer to hemodialysis
increases 4 times (p= 0.03). In both AISI and SII indices, the number of peritonitis was
statistically significant, for each peritonitis the risk of death or transfer to hemodialysis
increased by 2.34 (p= 0.02) and 1.79 times (p=0.04) . ), respectively. Conclusion: The present
study demonstrated that AISI > 149.61 and SII > 722.80 were independently associated with
the risk of death or transfer to hemodialysis in patients with PD. This is the first study carried
out in Brazil that investigated the association between hematological indices and general
mortality and transfer to HD, contributing to generating important evidence regarding the use
of practical and more accessible tools for detecting risks in the Brazilian population with RDC.

BANKING MEMBERS:
Externa à Instituição - ANA PAULA LUCAS MOTA - UFMG
Externa ao Programa - 2028750 - CAROLINE PEREIRA DOMINGUETI
Presidente - 1581667 - DANYELLE ROMANA ALVES RIOS
Externa ao Programa - 2332778 - LUCIANE TEIXEIRA PASSOS GIAROLA
Notícia cadastrada em: 02/02/2024 07:59
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