Banca de DEFESA: ALESSANDRA MARA DE SOUSA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : ALESSANDRA MARA DE SOUSA
DATE: 19/02/2021
TIME: 14:00
LOCAL: Videoconferência
TITLE:

In Vitro Study of the Compounds Antileishmania Activity SYNTHETIC DERIVED FROM CHALCONAS ON Leishmania (Viannia) braziliensis

KEY WORDS:

Em breve.

PAGES: 48
BIG AREA: Ciências da Saúde
AREA: Saúde Coletiva
SUMMARY:

Leishmaniasis are neglected diseases with a high incidence in developing countries, it is estimated that today, 350 million people are at risk of becoming infected and developing one of its clinical forms, totaling 2 million new cases annually.  The treatment is medication, however, due to the alarming scarcity of drugs in current clinical use and several side effects, in addition to reports of resistance associated with many of these drugs used as the first choice.  This whole context leads to the need for an urgent search for new drugs, whether they are of natural or synthetic origin.  The development of new drugs has been a challenge, mainly due to the resistance acquired by many parasites to conventional drugs.  In this work, the antileishmania potential of synthetic chalcones was evaluated, as already described in the literature, the presence of the α, β-unsaturated function, together with the type and position of the substituent in the aromatic rings, are often related to the biological activity leading.  When tested against the promastigote forms, the NFC and CH4OH derivatives, presented the most promising IC50 values and when tested against the amastigote forms, the CAdiCl, CH4OH derivatives showed the most promising IC50 values, being able to inhibit 50% of cell growth in the cultures of  L. braziliensis.  Most of the drugs approved for consumption are of natural origin, mainly in the areas of infectious diseases and cancer (BASTOS et al., 2016).  The promising chemical and pharmacological results demonstrated here enable the use of the chemical classes studied to represent new therapeutic possibilities, since their anti-inflammatory and antioxidant effects have already been described, in addition to being molecules with a great possibility of being manipulated thus allowing structural changes  , molecular and substitutions in its chemical structure, thus, it is possible to potentiate the effect against the pathogen, cause inhibition or activation of some enzyme, receptor, as well as to alter its pharmacokinetic and pharmacodynamic characteristics among several other activities (FAGAGNA et al., 2003  ).  Given the above, it is evident the importance of the search for new bioactive substances with antileishmania activity, whether of natural or synthetic origin as a source of chemotherapy compounds that have greater activity, less side effects and moderate cost (TIUMAN et al., 2011).

BANKING MEMBERS:
Externo à Instituição - RUBENS LIMA DO MONTE NETO - FIOCRUZ
Externa ao Programa - 1687272 - MARIANE CRISTINA SCHNITZLER VILLAR
Presidente - 1084423 - RAFAEL GONCALVES TEIXEIRA NETO