Banca de QUALIFICAÇÃO: LETICIA GONCALVES RESENDE FERREIRA

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : LETICIA GONCALVES RESENDE FERREIRA
DATE: 07/04/2021
TIME: 14:00
LOCAL: Videoconferência
TITLE:

THROMBINE GENERATION TEST, INCIDENCE OF MAJOR ELECTROCARDIOGRAPHIC CHANGES, GENERAL MORTALITY AND FOR CARDIOVASCULAR DISEASES IN ELSA-BRASIL

KEY WORDS:

Thrombin generation test, all-cause mortality, cardiovascular mortality

PAGES: 71
BIG AREA: Ciências da Saúde
AREA: Saúde Coletiva
SUMMARY:

Introduction: The strong interaction between inflammation and hemostasis places the thrombin as a possible biomarker of cardiovascular risk and the thrombin generation test (TGT) is a laboratorial method of diagnostic that allows her evaluation in plasma. The association between thrombin generation and cardiovascular events, mainly myocardial infarction (IAM) and stroke (AVE), all-cause mortality and cardiovascular mortality is still poorly investigated and the results are often inconsistent and inconsistent. The hypothesis of this work is that the TGT’s parameters can be predictor of cardiovascular events, fatal and non-fatal, and all-cause mortality and the objective was evaluated if the parameters ETP and peak were associated with all-cause mortality and cardiovascular mortality in a prospective cohort of Brazilian adults. Methods: This is a prospective cohort study in which was included 2,550 individuals who participated in the baseline (2008-2010) of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). The thrombin generation was measured by the TGT. The association between the TGT’s parameters, ETP and peak¸ in the baseline, and all-cause mortality and cardiovascular mortality was estimated by COX regression for univariate model and adjusted by different confounders. The mean time of follow-up was 9.48±1.12 years for all-cause mortality and 7.85±0.90 years for cardiovascular mortality. Results: In the univariate analysis, low values of ETP, in low concentration of tissue factor (FT), and ETP and peak, in high concentration of FT, were statistically associated with higher risk of all-cause death. However, after the adjusts for all confounders, was observed a weak association borderline between increase in ETP values in low concentration of FT and decrease in all-cause mortality [HR: 0.52 (0.27-1.00)]. Neither of the investigated parameters was associated with cardiovascular mortality. Conclusion: Our results show inverse association between ETP and all-cause mortality. So low values of ETP can be an important biomarker of risk of all-cause death.

BANKING MEMBERS:
Externa à Instituição - ALESSANDRA CARVALHO GOULART - USP
Externa à Instituição - MARIA DAS GRACAS CARVALHO - UFMG
Presidente - 1066935 - VINICIUS SILVA BELO