Banca de DEFESA: WANDER VALADARES DE OLIVEIRA JUNIOR

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : WANDER VALADARES DE OLIVEIRA JUNIOR
DATE: 17/09/2021
TIME: 09:00
LOCAL: Videoconferência
TITLE:

INFLAMMATION, PERITONEAL DYSFUNCTION AND MORTALITY GENERAL: LONGITUDINAL ANALYSIS IN PATIENTS SUBMITTED TO PERITONEAL DIALYSIS

KEY WORDS:

Peritoneal dialysis, inflammation, cytokines, peritoneal membrane, mortality, cardiovascular disease.

PAGES: 117
BIG AREA: Ciências da Saúde
AREA: Saúde Coletiva
SUMMARY:

Background: Progressive structural changes of the peritoneal membrane (PM) occur over time of treatment in peritoneal dialysis (PD), causing an increase in the chronic inflammatory process, increase in local and systemic cytokines, which can lead to the development and progression of cardiovascular disease (CVD), which can lead to increased overall mortality. Aim: To evaluate the association between plasma and dialysate levels of CCL2 and dialysate levels of CA-125 in patients undergoing PD and to evaluate inflammatory biomarkers in patients undergoing PD and to investigate the association of these with the occurrence of death by all causes. Method: Initially, a cross-sectional analysis was performed with 41 patients. Subsequently, a cohort was carried out with 43 patients, both undergoing PD. Cytokine assays (IL-6, IL-10, IL-17, TNF- and IFN-) were performed using flow cytometry. And the determination of CCL2 and CA-125 through capture ELISA. The investigation of the association between the CCL2 and CA-125 variables was carried out by means of crude arithmetic means and adjusted using generalized linear models. Cox regression analysis was used to estimate associations between mortality and median values of each cytokine and mortality. Results: A statistically significant association was found between dialysate levels of CCL2 and CA-125 (RMA=1.31; CI=1.20-1.43). A statistically significant association was also found between the cytokines IL-6 and IL-17 both on dialysate and the occurrence of overall mortality (p-value <0.05). Conclusion: The association of CA-125 levels with CCL2 in dialysate may indicate that the local inflammatory process leads to temporary or definitive changes in MP. IL-6 on dialysate has a positive predictive effect on death and IL-17 on dialysate has a protective effect against the risk of death in patients on PD. These biomarkers could be useful for possible decision-making, aiming to prolong the life of PM, as well as the PD technique, and could reduce the occurrence of premature deaths in this population.

BANKING MEMBERS:
Externa ao Programa - 1741307 - ADRIANA CRISTINA SOARES DE SOUZA
Externa à Instituição - ANDREA TEIXEIRA DE CARVALHO - FIOCRUZ
Presidente - 1581667 - DANYELLE ROMANA ALVES RIOS
Externa ao Programa - 2332778 - LUCIANE TEIXEIRA PASSOS GIAROLA
Externo à Instituição - THYAGO PROENCA DE MORAES - PUC-PR