Banca de DEFESA: GILCELIA CORREIA SANTOS BERNARDES

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : GILCELIA CORREIA SANTOS BERNARDES
DATE: 30/09/2021
TIME: 14:00
LOCAL: Videoconferência
TITLE:

BIOCHEMICAL AND HEMATOLOGICAL CHANGES CHARACTERISTIC OF AGING IN PEOPLE LIVING WITH HIV

KEY WORDS:

Aging, HIV, Biomarkers

PAGES: 46
BIG AREA: Ciências da Saúde
AREA: Saúde Coletiva
SUMMARY:

Introduction: HIV infection is a serious public health problem worldwide. The number of elderly people living with HIV has been increasing rapidly, due to the success of antiretroviral therapy and changes in lifestyle. Chronic inflammation caused by HIV and the effects of antiretroviral therapy has been associated with the premature aging of these individuals. So far, there is no consensus on the age at which an individual with HIV is considered elderly. Objective: Thus, this study aims to assess aging in people living with HIV through biomarkers. Method: This is a cross-sectional study developed with people living with HIV attended at the Specialized Care Service of Divinópolis-MG, from October 2019 to March 2021. A non-HIV group was used, selected from the national health survey database. Patients were divided into age groups: 18 to 49, 50 to 59, over 50 years and over 60 years and compared to biochemical and hematological variables. Results: When analyzing the renal function of the HIV and nonHIV group, over 60 years of age, no differences were found between the groups. However, when comparing the metabolic profile of the HIV group aged 50 to 59 years with the HIV group above 60 years, these were the same. Finally, when analyzing hematological data, these showed different patterns, while red blood cells in the 50 to 59 year group was the same as the over 60 years old group, in relation to hematocrit, the 50 to 59 year old group was the same as the 18 to 49 year old group years old. Conclusion: Therefore, our investigation demonstrates that for renal function and hematocrit the age cut-off would be from 60 years on, while for metabolic and red blood cells the ideal cut-off is from 50 years on. Our results are extremely important regarding dose adjustment and drug choice in people living with HIV at older ages, aiming at better therapeutic control.

BANKING MEMBERS:
Externa ao Programa - 1971548 - CRISTINA SANCHES
Presidente - 1544480 - EDUARDO SERGIO DA SILVA
Externa à Instituição - MARIA DAS GRACAS CARVALHO - UFMG
Interna - 1699263 - MELINA DE BARROS PINHEIRO INACIO