Banca de QUALIFICAÇÃO: VICTOR ANTONIO FERREIRA FREIRE

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : VICTOR ANTONIO FERREIRA FREIRE
DATE: 22/02/2022
TIME: 14:00
LOCAL: Videoconferência
TITLE:

EVALUATION OF OXIDATIVE STRESS IN PREECLAMPSIA: A SYSTEMATIC REVIEW

KEY WORDS:

Oxidative Damage, antioxidante enzyme, review Literature.

PAGES: 100
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:

Introduction: The preeclampsia is a hypertensive syndrome of pregnancy that presents severe complications during the gestation and high percentage of maternal and fetal morbidity. The inflammation, imbalance of angiogenic factors and oxidative stress has been targeted to study for further comprehension of its pathophysiology. Objective: This study aims to do a systematic review about the oxidative stress condition and evaluate which markers are altered in blood of placental tissue. Methods: In September a search was conducted in different databases such as MEDLINE, Embase, Lilacs, and Web of Science without restriction of year of publication. The quality of the studies was evaluated according to the Newcastle-Ottawa scale and Joanna Briggs Institute for analytical Cross-Sectional Studies. Results: From the 8255 screened records, 64 were finally included in the systematic review. The stress oxidative markers related to damage and antioxidant activity, such as malondialdehyde (MDA), lipid peroxides, hydrogen peroxide (H 2 O 2 ), oxide nitric (NO), advanced oxidation protein products, carbonylated protein, 8-hydroxy-2′-deoxyguanosine (8-OH-dG), total oxidant status
(TOS), and antioxidant activity, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione S-transferase (GST) and free glutathione (GSH). Perspectives: Among the next steps this review will include the risk evaluation of bias of the included studies, grey literature review, data analysis and manuscript writing.

BANKING MEMBERS:
Externa à Instituição - ESTELA MARIS ANDRADE FORELL BEVILACQUA - USP
Interno - 1039964 - ANDRE DE OLIVEIRA BALDONI
Presidente - 1544462 - HERICA DE LIMA SANTOS
Interna - 1699263 - MELINA DE BARROS PINHEIRO INACIO