Banca de DEFESA: VIRGÍNIA MOREIRA DE FREITAS

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : VIRGÍNIA MOREIRA DE FREITAS
DATE: 30/08/2022
TIME: 10:00
LOCAL: On line
TITLE:

Numerical Solution of the Temporal Dynamics of SARS-CoV-2 Infection: Storm cytokines

KEY WORDS:

SARS-CoV-2, Cytokine Storm, Biomathematics, Numerical Solution, Dynamics of Viral Infection.

PAGES: 67
BIG AREA: Ciências Exatas e da Terra
AREA: Matemática
SUBÁREA: Matemática Aplicada
SPECIALTY: Análise Numérica
SUMMARY:

In this work we will present a mathematical model that describes the temporal dynamics of SARS-CoV-2 infection in humans. WANG et al. (2020) elaborate a mathematical model for SARS-CoV-2 infection, where the target cells are type 2 pneumocytes (primary target) and lymphocytes (secondary target). In our model, we added a new variable, Interleukin 6 (IL-6), which is a pro-inflammatory cytokine and plays a key role in the evolution of the inflammatory immune response, the “cytokine storm”, which causes Discomfort Syndrome. Acute Respiratory Syndrome (ARDS). In addition, it is associated with a severe clinical condition of COVID-19. The problem is modeled through a system of nonlinear first order ordinary differential equations, which is numerically solved as an initial value problem. To obtain the parameters involved in the model, we used information on the viral load of the lower respiratory tract of patients who acquired COVID-19 in Germany (WANG et al., 2020) and those available in other literature. It is observed that the solution numerical model of the mathematical model is consistent with the clinical data available, in part, from some patients. The importance of understanding these mechanisms of action of the virus, as well as the action of the immune system, brings us evidence of how to develop treatment strategies to combat the disease COVID-19.

BANKING MEMBERS:
Presidente - 1671327 - JORGE ANDRES JULCA AVILA
Interno - 1714705 - JUAN CARLOS ZAVALETA AGUILAR
Externo à Instituição - GERMAN JESUS LOZADA CRUZ - UNESP