Banca de QUALIFICAÇÃO: ANNELISE SOUZA MELO

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : ANNELISE SOUZA MELO
DATE: 15/09/2023
TIME: 14:00
LOCAL: https://meet.google.com/bqt-byrt-zay
TITLE:

ENHANCED NUCLEOPHILIC FLUORATION OF AN AKYL BROMIDE UNDER CROWN ETHER CATALYSIS AND BDMB (1,4-BIS-2-(HYDROXY-2-PROPYL)BENZENE) OR TBOHF6 (1,1,1,3,3,3 -HEXAFLUORO-2-METHYL-2-PROPANOL

KEY WORDS:

nucleophilic fluorination, organic synthesis

PAGES: 24
BIG AREA: Ciências Exatas e da Terra
AREA: Química
SUBÁREA: Química Orgânica
SPECIALTY: Síntese Orgânica
SUMMARY:

The development of new fluorinated drugs depends on the advancement of synthetic methods of fluorination reactions. In the case of fluorinated aliphatic compounds, the great challenge is to use a cheap and widely available source of fluorine, such as potassium fluoride. Because it is sparingly soluble in polar aprotic solvents, has low reactivity in polar protic solvents, and because E2 reactions can occur in parallel, aliphatic fluorination with KF requires special catalysis via control of intermolecular forces. Recently, it was demonstrated by theoretical calculations, followed by experimental confirmation, that the use of crown ether combined with bulky alcohols leads to a nanostructured environment capable of solubilizing and activating the SN2 reaction involving KF. Using 1 mmol of BDMb diol, 1 mmol of substrate (RBr) and 1 mmol of crown ether (18C6) led to a yield of 22% in 24h of reaction in reflux of acetonitrile as solvent. Using tert-butanol instead of BDMb resulted in 13.5% yield. Minimal amounts of scavenging reaction by-product were obtained. In this work we repeated the experiments with BDMb and explored the use of another alcohol, a hexaflorinated tert-butanol (TBOHF6) reaching a yield of 80%, demonstrating that this alcohol presents very effective results.

BANKING MEMBERS:
Presidente - 3125781 - RAFAEL MAFRA DE PAULA DIAS
Externa ao Programa - 1544781 - STELLA MARIS RESENDE