Banca de DEFESA: VANESSA DO CARMO MARTINS

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : VANESSA DO CARMO MARTINS
DATE: 06/03/2024
TIME: 19:00
LOCAL: REMOTO
TITLE:

3D-printed syringe pump by additive manufacturing applied to the oxidation reaction in continuous flow regime

KEY WORDS:

flow chemistry, 3D-printing, alcohol oxidation, green chemistry

PAGES: 88
BIG AREA: Ciências Exatas e da Terra
AREA: Química
SUBÁREA: Química Orgânica
SPECIALTY: Síntese Orgânica
SUMMARY:

Green chemistry aims to develop processes that minimize or eliminate the use and generation of harmful substances to the environment. In this context, flow chemistry is an important ally as it enables better reaction control, reduced waste generation, and faster and more efficient reactions. However, flow systems require specific and costly equipment. As an alternative, additive manufacturing (3D printing) allows for the on-demand production of objects from accessible polymers, reducing production costs, minimizing material waste, and becoming relevant and promising for the construction of continuous flow devices. In this study, different components used in flow chemistry were 3D printed via additive manufacturing and applied in an oxidation reaction. After literature refinement, two models of syringe pumps were printed, constructed, and calibrated, both exhibiting similar accuracy to commercial pumps. Three reactors were also selected and printed after prospecting, as well as a set of connectors and mixers (T, Y, and cross-shaped). Samples in PLA were subjected to chemical sensitivity tests, revealing low resistance to pure aprotic polar solvents at boiling point. With the printed and assembled system, tests for the oxidation reaction of benzyl alcohol to benzaldehyde were conducted using I2 – KI – K2CO3 as the oxidizing medium. The reaction failed in the printed reactor due to clogging, requiring further studies. Alternatively, replacing the printed reactor with a commercial PFA reactor and conducting new assays resulted in the successful reaction with a yield of 78%, highlighting the novelty of this continuous flow reaction protocol. Ultimately, additive manufacturing demonstrates great potential to be explored in the construction of objects for continuous flow chemistry, and its validation in relevant chemical reactions.

BANKING MEMBERS:
Externo à Instituição - GUSTAVO SENRA GONCALVES DE CARVALHO
Presidente - 3125781 - RAFAEL MAFRA DE PAULA DIAS
Externo ao Programa - 1280597 - VAGNER FERNANDES KNUPP