Banca de DEFESA: BRUNO HENRIQUE COSTA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : BRUNO HENRIQUE COSTA
DATE: 19/02/2021
TIME: 14:00
LOCAL: Google meet pelo endereço: meet.google.com/poo-gsek-hwu
TITLE: 
STUDY OF THE SYSTEMIC EFFECTS OF ORAL TOLERANCE ON BONE DEFECT REPAIR PROCESS IN WISTAR RATS

KEY WORDS:
Bone repair, bone healing, oral tolerance, systemic effects, indirect effects

PAGES: 111
BIG AREA: Ciências Biológicas
AREA: Morfologia
SUMMARY:
With the increase in longevity the number of bone injuries has increased
significantly, being related to falls and / or metabolic disorders, such as
osteoporosis, which can affect the bone repair and remodeling process. The bone
repair process occurs in 3 overlapping phases: Inflammatory, callus formation
and remodeling. A critical phase in the repair of bone injuries is inflammatory,
since it is where migrations of cells such as macrophages, neutrophils,
lymphocytes to the injury site occur and the production of cytokines and growth
factors that will regulate all the kinetics of the repair, affecting you positively or
negatively. A phenomenon that has been shown to reduce inflammatory effects
is the systemic effects of oral tolerance, as already demonstrated in improving
skin wound repair, decreasing the size of granulomas, among others. However,
to date, there is no record of studies on the effects of oral tolerance in the repair
process of injured bone tissue. In this work we investigate whether the effects of
oral toleration with i.p. of the zein protein (component of the ration of rats)
adsorbed on aluminum hydroxide on the day that the bone defect was made in
tibias of male Wistar rats, interferes in the repair process 7, 14 and 28 days after
injury the bone tissue by histopathological analyzes, X-ray, digital computed
tomography and mechanical strength. The weighing of the humerus revealed that
the possible adaptation of the animals after the surgical procedure does not
interfere with the bone mass of the humerus. The tibial weights were also
measured and suggest that the tolerance maintains the weight of the injured tibia
in the periods of 14 and 28 days similar to that of the uninjured tibia of the animal
memo, while the other groups showed an increase in weight in the injured tibia
compared to the your control. The findings of this work reveal an acceleration in
the repair process in animals treated with zein in the periods of 7 and 14 days by
histomorphometry. The quality of the newly formed bone of animals tolerated by
means of mechanical tests reveals by BMD and X-ray that animals tolerated at
28 days after the injury show increased mineralization at the injury site in addition
to greater support for mechanical loads, observed in flexion test supported. The
results of digital computed tomography revealed an increase in mineralization of the lesion site in animals tolerated 45 days after the surgical procedure.
Morphological analyzes of the spleens did not show significant differences in the
studied periods. Thus, this work was a pioneer in the study of the effects of oral
zein tolerance on bone repair, demonstrating significant improvement in the bone
defect repair process. Further studies are needed to better understand the effects
of oral tolerance on tissue and the bone repair process.


BANKING MEMBERS:
Externo à Instituição - MARCOS AUGUSTO DE SÁ - UFMG
Externo ao Programa - 2362132 - ALVARO CESAR DE OLIVEIRA PENONI
Interno - 592.621.506-44 - CLAUDIA ROCHA CARVALHO - UFMG
Presidente - 2279745 - ERIKA LORENA FONSECA COSTA DE ALVARENGA
Interno - 1673132 - LUCIANO RIVAROLI
Interna - 2104326 - RAQUEL ALVES COSTA
Notícia cadastrada em: 05/02/2021 18:21
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