Banca de DEFESA: GENIANE VIANA RABELO

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : GENIANE VIANA RABELO
DATE: 31/05/2021
TIME: 14:00
LOCAL: google meet : meet.google.com/pmf-cutg-rry
TITLE:

EFEITO DO Ageratum conyzoides SOBRE ÓRGÃOS DE MUSCULATURA LISA

 

Effects of Ageratum conyzoides on smooth muscle 

KEY WORDS:

Ageratum conyzoides, nifedipine, vas deferens, jejunum.

PAGES: 85
BIG AREA: Ciências Biológicas
AREA: Farmacologia
SUMMARY:

Medicinal plants are widely used in folk medicine, among them we have the species Ageratum conyzoides, popularly known as "mentrasto". This is a tropical plant, which has a wide variety of secondary metabolites that include terpenes, steroids and alkaloides, plus essential oils. A. conyzoides is used in folk medicine for the treatment of fevers, ulcers and inflammatory diseases. Some studies have shown the beneficial effect of aqueous fraction of A. conyzoides on benign prostatic hyperplasia, antitumor effect and relaxation of the jejunum, duodenum and uterus. There is no work in the literature demonstrating the effect of the essential oil of A. conyzoides, so the objective this work was to evaluate the effect of the essential oil of A. conyzoides on the contraction of smooth muscle organs, as well as to try to describe possible mechanism of action. To perform the experiments, vas deferens and mouse jejunum were used. These organs were stimulated respectively with KCl, adrenaline and KCl and carbacol. Increasing doses of essential oil of A. conyzoides were preincubated in the presence and absence of nifedipine. To compare the effect of the oil with the effect of nifedipine, IC50 was used. Phytochemical analysis showed that precocen I is in greater quantity in our oil. The essential oil of A. conyzoides was able to inhibit both the phasic component and the tonic component of KCl or adrenaline-induced vas deferens contraction. Nifedipine also inhibited contraction. The effect of A. conyzoides was enhanced in the presence of nifedipine, being the phasic component KCl contraction and the phasic and tonic components of the most sensitive adrenaline-induced contraction than the effect only of A. conyzoides on its components. In the jejunum, the phasic composition of KCl-induced contraction is more sensitive to the action of A. conyzoides than the tonic. In the presence of nifedipine the effect of the oil was enhanced, but only on the phasic component. In this way, our results suggest that the essential oil of A. conyzoides can inhibit voltage-gated calcium channels and may be acting in another mechanism responsible for inhibiting muscle contraction of smooth muscle organs.

BANKING MEMBERS:
Presidente - 2144084 - PRISCILA TOTARELLI MONTEFORTE
Interno - 1673132 - LUCIANO RIVAROLI
Interna - 1742558 - FLAVIA CARMO HORTA PINTO
Externo à Instituição - EDILSON DANTAS DA SILVA JUNIOR - UFRN