Banca de DEFESA: MATHEUS VIANA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : MATHEUS VIANA
DATE: 22/12/2021
TIME: 08:00
LOCAL: Apresentação virtual devido pandemia de COVID-19.
TITLE:

Effect of Ageratum conzyzoides essential oil on uterine contractions and the influence of hormonal changes in the estrous cycle and castration on this effect.

KEY WORDS:

Ageratum conyzoides; essential oil; uterus; contraction; estrus cycle; castration.

PAGES: 68
BIG AREA: Ciências Biológicas
AREA: Farmacologia
SUMMARY:

Medicinal plants are an important therapeutic source, being used in the treatment of innumerous pathologies. Ageratum conyzoides is a species from the Asteraceae family popularly known as “mentrasto” or “caatinga-de-bode” and commonly used against pelvic discomforts besides reports of anti-inflammatory, anti-biotic and analgesic actions, among others. Some papers have described the relaxing activity of A. conyzoides in smooth muscule. However, there is no evidence around its essential oil relaxing action on uterine contractions. Thus, the main objective was to study A. conyzoides essential oil effects in uterus and the influence of the stage of estrus cycle and castration on it as well as try to elucidate its action mechanism. Female Swiss mice were or castrated or selected in different stages of the estrus cycle (oestrus and diestrus). In each group, contractions were induced on isolated uterus stripes in vitro by potassium chloride (KCl; 80mM) in the organ bath system, preceded by different concentrations of A. conyzoides essential oil and/or nifedipine, a classic voltage-gated calcium channel blocker. The results show that A. conyzoides essential oil effectively inhibit both phasic and tonic components of the uterine contraction induced by KCl. Hormonal changes during estrus cycle do not influence in the oil’s relaxing activity and castrated females display a more sensitive to its effect.  Nifedipine potentiates the oil’s effect only upon the inhibition of the tonic component of uterine contraction from females in oestus, suggesting that the oil may be acting so much in voltage-gated calcium channels as well as another mechanism related to the signalization involved in the contraction and relaxation dynamics. This founding show that Ageratum conyzoides essential oil can be used in the clinic against disfunctions associated to exacerbated uterine contractions.

BANKING MEMBERS:
Presidente - 2144084 - PRISCILA TOTARELLI MONTEFORTE
Interna - 1742558 - FLAVIA CARMO HORTA PINTO
Interno - 2141553 - PAULO HENRIQUE DE ALMEIDA CAMPOS JUNIOR
Externo ao Programa - 1908201 - JOAQUIM MAURICIO DUARTE ALMEIDA
Externo à Instituição - EDILSON DANTAS DA SILVA JUNIOR - UFRN